Gene Symbol | PLXNA1 |
---|---|
Entrez Gene | 5361 |
Alt Symbol | NOV, NOVP, PLEXIN-A1, PLXN1 |
Species | Human |
Gene Type | protein-coding |
Description | plexin A1 |
Other Description | plexin 1|plexin-A1|semaphorin receptor NOV |
Swissprots | Q9UIW2 |
Accessions | EAW79349 EAW79350 EAW79351 Q9UIW2 AI472001 AK054675 AK055605 AK126101 BAC86440 AK127254 AK128612 BAG54700 AK293425 BAG56931 AL136663 BC017323 BC032432 BC042904 BC156129 AAI56130 BC157020 AAI57021 BQ920360 X87832 CAB57274 XM_011512908 XP_011511210 XM_011512909 XP_011511211 NM_032242 NP_115618 |
Function | Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000250}. |
Tissue Specificity | Detected in fetal brain, lung, liver and kidney. {ECO:0000269|PubMed:8570614}. |
Top Pathways | Axon guidance |
Plexin A1 Antibody - 3813 from Cell Signaling Technology
|
||||||||||
plexin-A1 (Q-15) - sc-10138 from Santa Cruz Biotechnology
|
||||||||||
plexin-A1 (H-60) - sc-25639 from Santa Cruz Biotechnology
|
||||||||||
plexin-A1 (S-16) - sc-10139 from Santa Cruz Biotechnology
|
||||||||||
Anti-Plexin A1 antibody - ab23391 from Abcam
|
||||||||||
Anti-Plexin A1 antibody - ab32960 from Abcam
|
||||||||||
Anti-Plexin A1 antibody [EPR3449] - ab92346 from Abcam
|
||||||||||
Anti-PLXNA1 / Plexin A1 Antibody (aa986-1152, clone 11n153) - LS-C184872 from LifeSpan Bioscience
|
||||||||||
Anti-PLXNA1 / Plexin A1 Antibody (FITC) - LS-C316777 from LifeSpan Bioscience
|
||||||||||
Anti-PLXNA1 / Plexin A1 Antibody - LS-C285732 from LifeSpan Bioscience
|
||||||||||
Anti-PLXNA1 / Plexin A1 Antibody (HRP) - LS-C316778 from LifeSpan Bioscience
|
||||||||||
Anti-PLXNA1 / Plexin A1 Antibody (Biotin) - LS-C318736 from LifeSpan Bioscience
|
||||||||||
Anti-PLXNA1 / Plexin A1 Antibody (aa43-300) - LS-C315000 from LifeSpan Bioscience
|
||||||||||
Anti-PLXNA1 / Plexin A1 Antibody (Extracellular Domain, clone EPR3449) - LS-C105577 from LifeSpan Bioscience
|
||||||||||
Plexin A1 Antibody (659807) - MAB6536 from Novus Biologicals
|
||||||||||
Plexin A1 Antibody - NBP1-82544 from Novus Biologicals
|
||||||||||
Plexin A1 Polyclonal Antibody - bs-2692R from Bioss
|
||||||||||
Rabbit Anti-AX2R Polyclonal Antibody - bs-7669R from Bioss
|
||||||||||
Anti-PLXNA1 antibody produced in rabbit - SAB4301102 from Sigma-Aldrich
|
||||||||||
Anti-PLXNA1 antibody produced in rabbit - HPA007499 from Sigma-Aldrich
|
||||||||||
Plexin-A1-Antibody - AJ1637a from Abgent, a WuXi AppTec company
|
||||||||||
Human/Mouse Plexin A1 Antibody - AF4309 from R&D Systems
|
||||||||||
Mouse Plexin A1 Affinity Purified Polyclonal Ab, Goat IgG - AF4309-SP from R&D Systems
|
||||||||||
Mouse Plexin A1 APC-conjugated Antibody - FAB4309A from R&D Systems
|
||||||||||
Mouse Plexin A1 Alexa Fluor® 488-conjugated Antibody - FAB4309G from R&D Systems
|