| Gene Symbol |
VPS37A
|
| Entrez Gene |
137492
|
| Alt Symbol |
HCRP1, PQBP2, SPG53
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vacuolar protein sorting 37 homolog A (S. cerevisiae)
|
| Other Description |
ESCRT-I complex subunit VPS37A|hepatocellular carcinoma-related protein 1|polyglutamine binding protein 2|vacuolar protein sorting-associated protein 37A
|
| Swissprots |
Q6NW27 Q96DL9 Q336D5 Q8TBL7 Q8NEZ2 Q8N3D7
|
| Accessions |
EAW63817 EAW63818 EAW63819 Q8NEZ2 AF547097 AAQ12067 AK057204 BAB71381 AK090607 AK124607 BAG54057 AY033079 AAK54349 BC022363 AAH22363 BC067754 AAH67754 HQ447456 ADQ31942 XM_005273400 XP_005273457 XM_005273401 XP_005273458 XM_006716286 XP_006716349 NM_001145152 NP_001138624 NM_152415 NP_689628
|
| Function |
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15240819}.
|
| Subcellular Location |
Late endosome membrane; Peripheral membrane protein. Nucleus.
|
| Tissue Specificity |
Widely expressed. Examined tissues include heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. More abundant in liver. Strongly decreased or undetected in hepatomas. {ECO:0000269|PubMed:14623289, ECO:0000269|PubMed:22717650}.
|
| Top Pathways |
Endocytosis
|
![Western Blot: VPS37A Overexpression Lysate (Adult Normal) [NBP2-05385] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for VPS37A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/17444_VPS37A%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-05385-img0001.jpg)