Gene Symbol | VPS37A |
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Entrez Gene | 137492 |
Alt Symbol | HCRP1, PQBP2, SPG53 |
Species | Human |
Gene Type | protein-coding |
Description | vacuolar protein sorting 37 homolog A (S. cerevisiae) |
Other Description | ESCRT-I complex subunit VPS37A|hepatocellular carcinoma-related protein 1|polyglutamine binding protein 2|vacuolar protein sorting-associated protein 37A |
Swissprots | Q6NW27 Q96DL9 Q336D5 Q8TBL7 Q8NEZ2 Q8N3D7 |
Accessions | EAW63817 EAW63818 EAW63819 Q8NEZ2 AF547097 AAQ12067 AK057204 BAB71381 AK090607 AK124607 BAG54057 AY033079 AAK54349 BC022363 AAH22363 BC067754 AAH67754 HQ447456 ADQ31942 XM_005273400 XP_005273457 XM_005273401 XP_005273458 XM_006716286 XP_006716349 NM_001145152 NP_001138624 NM_152415 NP_689628 |
Function | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15240819}. |
Subcellular Location | Late endosome membrane; Peripheral membrane protein. Nucleus. |
Tissue Specificity | Widely expressed. Examined tissues include heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. More abundant in liver. Strongly decreased or undetected in hepatomas. {ECO:0000269|PubMed:14623289, ECO:0000269|PubMed:22717650}. |
Top Pathways | Endocytosis |
VPS37 (E-16) - sc-50190 from Santa Cruz Biotechnology
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VPS37 (S-18) - sc-50192 from Santa Cruz Biotechnology
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VPS37 (T-20) - sc-50193 from Santa Cruz Biotechnology
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VPS37A (G-3) - sc-376978 from Santa Cruz Biotechnology
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VPS37A (H-300) - sc-98470 from Santa Cruz Biotechnology
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Anti-VPS37A antibody - ab177055 from Abcam
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Anti-VPS37A antibody - ab85843 from Abcam
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Anti-VPS37A Antibody - LS-C294474 from LifeSpan Bioscience
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Anti-VPS37A Antibody (Biotin) - LS-C297397 from LifeSpan Bioscience
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Anti-VPS37A Antibody (FITC) - LS-C305000 from LifeSpan Bioscience
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Anti-VPS37A Antibody (N-Terminus) - LS-C102498 from LifeSpan Bioscience
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Anti-VPS37A Antibody - LS-C331497 from LifeSpan Bioscience
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VPS37A Antibody - NBP1-83528 from Novus Biologicals
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VPS37A Antibody - NBP1-03431 from Novus Biologicals
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VPS37A Antibody - NBP1-81994 from Novus Biologicals
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Anti-VPS37A antibody produced in rabbit - HPA024781 from Sigma-Aldrich
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Anti-VPS37A antibody produced in rabbit - HPA024705 from Sigma-Aldrich
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VPS37A antibody - N-terminal region (ARP52954_P050) - ARP52954_P050 from Aviva Systems Biology
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VPS37A antibody - 70R-21271 from Fitzgerald
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VPS37A antibody - 70R-2831 from Fitzgerald
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HCRP1 Polyclonal Antibody - A1505 from ABclonal
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VPS37A Antibody - abx037035 from Abbexa
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VPS37A antibody - 11870-1-AP from Acris Antibodies
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Anti-HCRP1, Polyclonal Antibody - 25-A1505 from ARP American Research Products
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Anti-Hepatocellular Carcinoma Related Protein 1 (HCRP1) - 20-5633 from ARP American Research Products
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