Gene Symbol | VPS37A |
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Entrez Gene | 137492 |
Alt Symbol | HCRP1, PQBP2, SPG53 |
Species | Human |
Gene Type | protein-coding |
Description | vacuolar protein sorting 37 homolog A (S. cerevisiae) |
Other Description | ESCRT-I complex subunit VPS37A|hepatocellular carcinoma-related protein 1|polyglutamine binding protein 2|vacuolar protein sorting-associated protein 37A |
Swissprots | Q6NW27 Q96DL9 Q336D5 Q8TBL7 Q8NEZ2 Q8N3D7 |
Accessions | EAW63817 EAW63818 EAW63819 Q8NEZ2 AF547097 AAQ12067 AK057204 BAB71381 AK090607 AK124607 BAG54057 AY033079 AAK54349 BC022363 AAH22363 BC067754 AAH67754 HQ447456 ADQ31942 XM_005273400 XP_005273457 XM_005273401 XP_005273458 XM_006716286 XP_006716349 NM_001145152 NP_001138624 NM_152415 NP_689628 |
Function | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15240819}. |
Subcellular Location | Late endosome membrane; Peripheral membrane protein. Nucleus. |
Tissue Specificity | Widely expressed. Examined tissues include heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. More abundant in liver. Strongly decreased or undetected in hepatomas. {ECO:0000269|PubMed:14623289, ECO:0000269|PubMed:22717650}. |
Top Pathways | Endocytosis |
Human-VPS37A-cDNA-Clone - DC08619 from Abgent, a WuXi AppTec company
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VPS37A - MBS1271861 from MyBioSource
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VPS37A - MBS1278536 from MyBioSource
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Human VPS37A cDNA clone(NM_001145152.1) - CDFH021126 from Creative Biomart
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human VPS37A ORF clone - CDCH100196 from Creative Biomart
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human VPS37A ORF clone - CDCH100197 from Creative Biomart
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human VPS37A ORF clone - CDCH100198 from Creative Biomart
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human VPS37A ORF clone - CDCH100199 from Creative Biomart
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human VPS37A ORF clone - CDCH100200 from Creative Biomart
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human VPS37A ORF clone - CDCH100201 from Creative Biomart
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Human VPS37A ORF Clone(NM_001145152.1) - CDCL180975 from Creative Biomart
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Human VPS37A ORF Clone(NM_001145152.1) - CDCL180976 from Creative Biomart
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Human VPS37A ORF Clone(NM_001145152.1) - CDCR352535 from Creative Biomart
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Human VPS37A ORF Clone(NM_001145152.1) - CDCR352536 from Creative Biomart
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human VPS37A ORF clone (NM_001145152.1) - CDCH100196 from Creative biogene
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Human VPS37A ORF Clone (BC022363) - CDCS408460 from Creative biogene
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Human VPS37A ORF Clone (BC067754) - CDCS408461 from Creative biogene
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Human VPS37A cDNA Clone(NM_001145152.1) - CDFH021126 from Creative biogene
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