| Gene Symbol |
QTRT1
|
| Entrez Gene |
81890
|
| Alt Symbol |
FP3235, TGT, TGUT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
queuine tRNA-ribosyltransferase 1
|
| Other Description |
TGT, 43-KD subunit|TGT, catalytic subunit|guanine insertion enzyme|queuine tRNA-ribosyltransferase|tRNA-guanine transglycosylase
|
| Swissprots |
B4DFM7 Q9BXR0 Q9BXQ9 Q96BQ4
|
| Accessions |
EAW84138 EAW84139 EAW84140 EAW84141 EAW84142 EAW84143 Q9BXR0 AF302783 AAG60033 AF302784 AAG60034 AF302785 AF370379 AAQ15215 AK055216 AK057877 AK225173 AK294166 BAG57488 AK314308 BAG36960 BC015350 AAH15350 CT003728 NM_031209 NP_112486
|
| Function |
Interacts with QTRTD1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Note=Weakly associates with mitochondria, possibly via QTRTD1. {ECO:0000250}.
|