Gene Symbol | QTRT1 |
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Entrez Gene | 81890 |
Alt Symbol | FP3235, TGT, TGUT |
Species | Human |
Gene Type | protein-coding |
Description | queuine tRNA-ribosyltransferase 1 |
Other Description | TGT, 43-KD subunit|TGT, catalytic subunit|guanine insertion enzyme|queuine tRNA-ribosyltransferase|tRNA-guanine transglycosylase |
Swissprots | B4DFM7 Q9BXR0 Q9BXQ9 Q96BQ4 |
Accessions | EAW84138 EAW84139 EAW84140 EAW84141 EAW84142 EAW84143 Q9BXR0 AF302783 AAG60033 AF302784 AAG60034 AF302785 AF370379 AAQ15215 AK055216 AK057877 AK225173 AK294166 BAG57488 AK314308 BAG36960 BC015350 AAH15350 CT003728 NM_031209 NP_112486 |
Function | Interacts with QTRTD1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Note=Weakly associates with mitochondria, possibly via QTRTD1. {ECO:0000250}. |
QTRT1 CRISPR/Cas9 KO Plasmid (h) - sc-413456 from Santa Cruz Biotechnology
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QTRT1 HDR Plasmid (h) - sc-413456-HDR from Santa Cruz Biotechnology
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QTRT1 Double Nickase Plasmid (h) - sc-413456-NIC from Santa Cruz Biotechnology
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QTRT1 Double Nickase Plasmid (h2) - sc-413456-NIC-2 from Santa Cruz Biotechnology
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QTRT1 CRISPR Activation Plasmid (h) - sc-413456-ACT from Santa Cruz Biotechnology
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QTRT1 CRISPR Activation Plasmid (h2) - sc-413456-ACT-2 from Santa Cruz Biotechnology
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QTRT1 Lentiviral Activation Particles (h) - sc-413456-LAC from Santa Cruz Biotechnology
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QTRT1 Lentiviral Activation Particles (h2) - sc-413456-LAC-2 from Santa Cruz Biotechnology
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QTRT1 siRNA (h) - sc-97223 from Santa Cruz Biotechnology
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QTRT1 shRNA Plasmid (h) - sc-97223-SH from Santa Cruz Biotechnology
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QTRT1 shRNA (h) Lentiviral Particles - sc-97223-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU219041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17795 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17795 from Sigma-Aldrich
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QTRT1 siRNA (Human) - CRJ3080 from Cohesion Biosciences
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QTRT1 - MBS8211241 from MyBioSource
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shRNA set against Human QTRT1 (NM_031209.2) - SHH387720 from Creative biogene
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Human QTRT1 siRNA - orb273581 from Biorbyt
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QTRT1 shRNA Plasmid (Human) - CHJ3080 from Cohesion Biosciences
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QTRT1 miRNA 3'UTR clone - MiUTR3H-10713 from Creative biogene
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