HTR2C

Gene Symbol HTR2C
Entrez Gene 3358
Alt Symbol 5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C
Species Human
Gene Type protein-coding
Description 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Other Description 5-hydroxytryptamine receptor 1C|5-hydroxytryptamine receptor 2C|serotonin 5-HT-1C receptor|serotonin 5-HT-2C receptor
Swissprots Q9NP28 Q5VUF8 P28335 B1AMW4
Accessions AAC71658 ACE96318 ACE96323 ACE96328 CAB59978 EAX02623 EAX02624 P28335 AF208053 AAF35842 AF498983 AAM21130 AK295753 BAG58583 AK308766 AY114104 AAM78371 BC028688 BC095543 AAH95543 BX648587 FJ200493 ACO54890 M81778 AAA60317 U49516 AAB40898 NM_000868 NP_000859 NM_001256760 NP_001243689 NM_001256761 NP_001243690
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1- 2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release o
Subcellular Location Cell membrane {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}; Multi-pass membrane protein {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}.
Tissue Specificity Detected in brain. {ECO:0000269|PubMed:8812491}.
Top Pathways Gap junction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction

SR-2C (D-12) - sc-17797 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SR-2C (D-12): sc-17797. Western blot analysis of SR-2C expression in mouse (A) and rat (B) brain extracts.

SR-2C (C-20) - sc-1464 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SR-2C (C-20): sc-1464. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of exocrine glandular cells, Islets of Langerhans and pancreatic duct cells.

SR-2C (H-85) - sc-10802 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SR-2C (H-85): sc-10802. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of exocrine glandular cells and Islets of Langerhans.

SR-2C (N-19) - sc-15081 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SR-2C (N-19): sc-15081. Western blot analysis of SR-2C expression in SK-N-MC (A) and SH-SY5Y (B) whole cell lysates.

Anti-5HT2C Receptor antibody - ab197776 from Abcam

Prices $378.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed, paraffin-embedded Human brain cerebellum tissue, labeling 5HT2C Receptor using ab197776 at 5 µg/ml

Anti-5HT2C Receptor antibody - ab44640 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-5HT2C Receptor antibody - ab37293 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab37293 stained PC12 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab37293, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-5HT2C Receptor antibody - ab134389 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human prostate tissue labelling 5HT2C Receptor with ab134389 antibody at a concentration of 10 µg/ml, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-5HT2C Receptor antibody - ab136849 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-5HT2C Receptor antibody (ab136849) at 1/500 dilution + K562 cell lysate at 30 µg

Anti-5HT2C Receptor antibody [EPR6486] - ab124951 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6486
All lanes : Anti-5HT2C Receptor antibody [EPR6486] (ab124951) at 1/1000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : A431 cell lysateLane 3 : BxPC-3 cell lysateLysates/proteins at 10 µg per lane.Secondarystandard HRP labelled goat anti-rabbit at 1/2000 dilution

Anti-5HT2C Receptor antibody [EPR6487] - ab133570 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6487
All lanes : Anti-5HT2C Receptor antibody [EPR6487] (ab133570) at 1/1000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : BXPC3 cell lysateLane 3 : MOLT4 cell lysateLane 4 : Mouse kidney lysateLane 5 : Rat kidney lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilutiondeveloped using the ECL technique

Anti-5HT2C Receptor antibody - C-terminal - ab140516 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded Human kidney, renal tubules tissue labelling 5HT2C Receptor with ab140516 at 3.8 µg/ml.

Anti-HTR2C / 5-HT2C Receptor Antibody (aa43) - LS-C190246 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTR2C / 5-HT2C Receptor Antibody (aa252-282, APC) - LS-C222793 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR2C / 5-HT2C Receptor Antibody (Pro190) - LS-C193129 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTR2C / 5-HT2C Receptor Antibody - LS-C48625 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of HTR2C / 5-HT2C antibody LS-C48625.

Anti-HTR2C / 5-HT2C Receptor Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1116 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-5HT2C Receptor antibody LS-A1116 IHC of human pancreas, ganglion and Schwann cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HTR2C / 5-HT2C Receptor Antibody (aa395-444) - LS-C120545 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat cells, using HTR2C Antibody. The lane on the right is treated with the synthesized peptide.

Anti-HTR2C / 5-HT2C Receptor Antibody (aa252-282, FITC) - LS-C222795 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR2C / 5-HT2C Receptor Antibody (aa252-282, Biotin) - LS-C222794 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR2C / 5-HT2C Receptor Antibody (aa252-282, PE) - LS-C226796 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR2C / 5-HT2C Receptor Antibody (aa252-282, Azide-free, HRP) - LS-C226793 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR2C / 5-HT2C Receptor Antibody (aa252-282) - LS-C329651 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR2C / 5-HT2C Receptor Antibody (aa388-437) - LS-C292079 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTR2C / 5-HT2C Receptor Antibody (clone 1A8) - LS-C197474 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A8
Detection limit for recombinant GST tagged HTR2C is approximately 0.1 ng/ml as a capture antibody.
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