HTR2C

Gene Symbol HTR2C
Entrez Gene 3358
Alt Symbol 5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C
Species Human
Gene Type protein-coding
Description 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Other Description 5-hydroxytryptamine receptor 1C|5-hydroxytryptamine receptor 2C|serotonin 5-HT-1C receptor|serotonin 5-HT-2C receptor
Swissprots Q9NP28 Q5VUF8 P28335 B1AMW4
Accessions AAC71658 ACE96318 ACE96323 ACE96328 CAB59978 EAX02623 EAX02624 P28335 AF208053 AAF35842 AF498983 AAM21130 AK295753 BAG58583 AK308766 AY114104 AAM78371 BC028688 BC095543 AAH95543 BX648587 FJ200493 ACO54890 M81778 AAA60317 U49516 AAB40898 NM_000868 NP_000859 NM_001256760 NP_001243689 NM_001256761 NP_001243690
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1- 2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release o
Subcellular Location Cell membrane {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}; Multi-pass membrane protein {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}.
Tissue Specificity Detected in brain. {ECO:0000269|PubMed:8812491}.
Top Pathways Gap junction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction

SR-2C CRISPR/Cas9 KO Plasmid (h) - sc-400886 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2C HDR Plasmid (h) - sc-400886-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2C Double Nickase Plasmid (h) - sc-400886-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2C Double Nickase Plasmid (h2) - sc-400886-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2C CRISPR Activation Plasmid (h) - sc-400886-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2C CRISPR Activation Plasmid (h2) - sc-400886-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2C Lentiviral Activation Particles (h) - sc-400886-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2C Lentiviral Activation Particles (h2) - sc-400886-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2C siRNA (h) - sc-42235 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SR-2C shRNA Plasmid (h) - sc-42235-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SR-2C shRNA (h) Lentiviral Particles - sc-42235-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU120291 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1830 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1830 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11673 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11673

HTR2C siRNA (Human) - CRH2288 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

5-HT2C RNAi - H00003358-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

HTR2C - MBS8224517 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SR-2C CRISPR/Cas9 KO Plasmid (h2) - sc-400886-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SR-2C HDR Plasmid (h2) - sc-400886-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human HTR2C (NM_000868.2) - SHH315937 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human HTR2C(NM_000868.2) - SHH135749 from Creative biogene

Category siRNA
Species Reactivities Human

Human HTR2C siRNA - orb262790 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HTR2C shRNA Plasmid (Human) - CHH2288 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HTR2C miRNA 3'UTR clone - MiUTR1H-04754 from Creative biogene

Species Reactivities Human
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