| Gene Symbol |
HTR2C
|
| Entrez Gene |
3358
|
| Alt Symbol |
5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
|
| Other Description |
5-hydroxytryptamine receptor 1C|5-hydroxytryptamine receptor 2C|serotonin 5-HT-1C receptor|serotonin 5-HT-2C receptor
|
| Swissprots |
Q9NP28 Q5VUF8 P28335 B1AMW4
|
| Accessions |
AAC71658 ACE96318 ACE96323 ACE96328 CAB59978 EAX02623 EAX02624 P28335 AF208053 AAF35842 AF498983 AAM21130 AK295753 BAG58583 AK308766 AY114104 AAM78371 BC028688 BC095543 AAH95543 BX648587 FJ200493 ACO54890 M81778 AAA60317 U49516 AAB40898 NM_000868 NP_000859 NM_001256760 NP_001243689 NM_001256761 NP_001243690
|
| Function |
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1- 2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release o
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}; Multi-pass membrane protein {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}.
|
| Tissue Specificity |
Detected in brain. {ECO:0000269|PubMed:8812491}.
|
| Top Pathways |
Gap junction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction
|