HTR2C

Gene Symbol	HTR2C
Entrez Gene	3358
Alt Symbol	5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C
Species	Human
Gene Type	protein-coding
Description	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Other Description	5-hydroxytryptamine receptor 1C|5-hydroxytryptamine receptor 2C|serotonin 5-HT-1C receptor|serotonin 5-HT-2C receptor
Swissprots	Q9NP28 Q5VUF8 P28335 B1AMW4
Accessions	AAC71658 ACE96318 ACE96323 ACE96328 CAB59978 EAX02623 EAX02624 P28335 AF208053 AAF35842 AF498983 AAM21130 AK295753 BAG58583 AK308766 AY114104 AAM78371 BC028688 BC095543 AAH95543 BX648587 FJ200493 ACO54890 M81778 AAA60317 U49516 AAB40898 NM_000868 NP_000859 NM_001256760 NP_001243689 NM_001256761 NP_001243690
Function	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1- 2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release o
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}; Multi-pass membrane protein {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:7895773}.
Tissue Specificity	Detected in brain. {ECO:0000269|PubMed:8812491}.
Top Pathways	Gap junction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

5HT2C Receptor peptide - ab170038 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

5HT2C Receptor peptide - ab168550 from Abcam Category Peptide

Human 5HT2C Receptor protein fragment - ab114363 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Rat 5HT2C Receptor peptide - ab32171 from Abcam Category Peptide

HTR2C / 5-HT2C Receptor Antibody Blocking Peptide - LS-E2792 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HTR2C / 5-HT2C Receptor Antibody Blocking Peptide - LS-E25890 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HTR2C / 5-HT2C Receptor Antibody Blocking Peptide - LS-E28141 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HTR2C / 5-HT2C Receptor Antibody Blocking Peptide - LS-E28142 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HTR2C / 5-HT2C Receptor Antibody Blocking Peptide - LS-E28143 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human 5-HT2C Protein - H00003358-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HTR2C-Antibody-Center-Blocking-peptide - BP13896c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

5-HT2C receptor blocking peptide - GTX89555-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

HTR2C Blocking Peptide - 33R-8699 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HTR2C Blocking Peptide - 33R-10874 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

5HT2C receptor Peptide - AC21-0720-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Serotonin receptor 2C (HTR2C) - H00003358-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Serotonin receptor 2C (HTR2C) - H00003358-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Serotonin receptor 2C Peptide - 46-356P from ProSci Category Peptide Species Human

Recombinant Human HTR2C - HTR2C-26028TH from Creative Biomart Category Protein Source Wheat germ

Recombinant 5-Hydroxytryptamine Receptor 2C (HTR2C) - RPD488Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

ChemiSCREEN™ Membrane Preparation Recombinant Human sst 1 Somatostatin Receptor - HTS170M from EMD Millipore Prices $596.00 Sizes 200 units Species Human

ChemiSCREEN™ Human 5-HT 2C Receptor Membrane Preparation - HTS132M from EMD Millipore Prices $596.00 Sizes 200 units Species Human

SR-2C (Q437) Peptide - BS2766P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

SR-2C (P190) Peptide - BS9129P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

HTR2C Blocking Peptide - 3685RBP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

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