| Gene Symbol |
SUMO3
|
| Entrez Gene |
6612
|
| Alt Symbol |
SMT3A, SMT3H1, SUMO-3, Smt3B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
small ubiquitin-like modifier 3
|
| Other Description |
SMT3 suppressor of mif two 3 homolog 1|SMT3 suppressor of mif two 3 homolog 3|small ubiquitin-related modifier 3|ubiquitin-like protein SMT3B
|
| Swissprots |
P55854 Q6FGD4 B4DUW4 Q9BWR4 Q53HI9 B2R5X4
|
| Accessions |
EAX09390 EAX09391 EAX09392 EAX09393 P55854 AK222591 BAD96311 AK300822 BAG62476 AK312350 BAG35271 BC000036 AAH00036 BC008420 AAH08420 BT007008 AAP35654 CR542173 CAG46970 CR542188 CAG46985 X99584 CAA67896 NM_001286416 NP_001273345 NM_006936 NP_008867
|
| Function |
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Nucleus, PML body {ECO:0000250}.
|
| Tissue Specificity |
Expressed predominantly in liver. {ECO:0000269|PubMed:15487983}.
|
| Top Pathways |
RNA transport
|