Gene Symbol | SUMO3 |
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Entrez Gene | 6612 |
Alt Symbol | SMT3A, SMT3H1, SUMO-3, Smt3B |
Species | Human |
Gene Type | protein-coding |
Description | small ubiquitin-like modifier 3 |
Other Description | SMT3 suppressor of mif two 3 homolog 1|SMT3 suppressor of mif two 3 homolog 3|small ubiquitin-related modifier 3|ubiquitin-like protein SMT3B |
Swissprots | P55854 Q6FGD4 B4DUW4 Q9BWR4 Q53HI9 B2R5X4 |
Accessions | EAX09390 EAX09391 EAX09392 EAX09393 P55854 AK222591 BAD96311 AK300822 BAG62476 AK312350 BAG35271 BC000036 AAH00036 BC008420 AAH08420 BT007008 AAP35654 CR542173 CAG46970 CR542188 CAG46985 X99584 CAA67896 NM_001286416 NP_001273345 NM_006936 NP_008867 |
Function | Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678}. |
Subcellular Location | Cytoplasm. Nucleus. Nucleus, PML body {ECO:0000250}. |
Tissue Specificity | Expressed predominantly in liver. {ECO:0000269|PubMed:15487983}. |
Top Pathways | RNA transport |
Active human Sumo 3 full length protein - ab189693 from Abcam
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Active Sumo 3 full length protein - ab3802 from Abcam
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Human Sumo 3 full length protein - ab140414 from Abcam
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Human Sumo 3 full length protein - ab131972 from Abcam
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Human Sumo 3 full length protein - ab152093 from Abcam
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Human Sumo 3 full length protein - ab99866 from Abcam
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Human Sumo 3 full length protein - ab189690 from Abcam
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Human Sumo 3 full length protein - ab189730 from Abcam
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Human Sumo 3 full length protein - ab190018 from Abcam
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Human Sumo 3 full length protein - ab190038 from Abcam
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Human Sumo 3 full length protein - ab168888 from Abcam
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Human Sumo 3 protein fragment - ab159550 from Abcam
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Human Sumo 3 protein fragment - ab157052 from Abcam
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SUMO3 Antibody Blocking Peptide - LS-E30928 from LifeSpan Bioscience
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SUMO3 Antibody Blocking Peptide - LS-E16723 from LifeSpan Bioscience
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SUMO3 Antibody Blocking Peptide - LS-E21311 from LifeSpan Bioscience
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SUMO3 Recombinant Protein - H00006612-P01 from Novus Biologicals
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SUMO3 Partial Recombinant Protein - H00006612-Q01 from Novus Biologicals
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SUMO3 Blocking Peptide - NBP1-77164PEP from Novus Biologicals
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Recombinant Human SUMO3 Protein - NBP1-99840 from Novus Biologicals
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Recombinant Human SUMO3 Protein - NBP1-49438 from Novus Biologicals
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SUMO3 Peptide - P0288 from Novus Biologicals
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SUMO23-Antibody-C-term-Blocking-Peptide - BP1224a from Abgent, a WuXi AppTec company
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SUMO23-Antibody-Center-Blocking-Peptide - BP1223d from Abgent, a WuXi AppTec company
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Recombinant Human HA-SUMO3 Vinyl Sulfone, CF - UL-769-050 from R&D Systems
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