SUMO3

Gene Symbol SUMO3
Entrez Gene 6612
Alt Symbol SMT3A, SMT3H1, SUMO-3, Smt3B
Species Human
Gene Type protein-coding
Description small ubiquitin-like modifier 3
Other Description SMT3 suppressor of mif two 3 homolog 1|SMT3 suppressor of mif two 3 homolog 3|small ubiquitin-related modifier 3|ubiquitin-like protein SMT3B
Swissprots P55854 Q6FGD4 B4DUW4 Q9BWR4 Q53HI9 B2R5X4
Accessions EAX09390 EAX09391 EAX09392 EAX09393 P55854 AK222591 BAD96311 AK300822 BAG62476 AK312350 BAG35271 BC000036 AAH00036 BC008420 AAH08420 BT007008 AAP35654 CR542173 CAG46970 CR542188 CAG46985 X99584 CAA67896 NM_001286416 NP_001273345 NM_006936 NP_008867
Function Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678}.
Subcellular Location Cytoplasm. Nucleus. Nucleus, PML body {ECO:0000250}.
Tissue Specificity Expressed predominantly in liver. {ECO:0000269|PubMed:15487983}.
Top Pathways RNA transport

SUMO-2 (C-13) - sc-26972 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SUMO-2 (C-13): sc-26972. Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate tissue showing nuclear staining of glandular cells.

SUMO-2/3 (FL-103) - sc-32873 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SUMO-2/3 (FL-103): sc-32873. Western blot analysis of SUMO-2 expression in non-transfected: sc-117752 (A) and human SUMO-2 transfected: sc-111926 (B) 293T whole cell lysates.

SUMO-2/3 (N-18) - sc-26969 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SUMO-2/3 (N-18): sc-26969. Western blot analysis of SUMO-2/3 expression in rat brain tissue extract.

SUMO-2/3 (V-20) - sc-26970 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SUMO-3 (LW-M2) - sc-135572 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
SUMO-3 (LW-M2): sc-135572. Western blot analysis of SUMO-3 expression in human SUMO-3 transfected (A) and non-transfected (B) 293T whole cell lysates.

SUMO-3 (76AT630.91.31) - sc-130884 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
SUMO-3 (76AT630.91.31 ): sc-130884. Western blot analysis of SUMO-3 expression in GST-SUMO3 fusion protein (A) and Jurkat (B) whole cell lysate.

Anti-Sumo 2+3 antibody - ab22654 from Abcam

Prices $385.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-Sumo 2+3 antibody - ab80986 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Sumo 2+3 antibody - ab129292 from Abcam

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab129292, at 10&microg/ml, staining Sumo 2+3 in Formalin-fixed, Paraffin-embedded Human testis tissue by Immunohistochemistry.

Anti-Sumo 2+3 antibody - ab118632 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab118632 at 5 µg/ml staining Sumo 2+3 in Formalin-Fixed, Paraffin-Embedded Human Prostate tissue by Immunohistochemistry.

Anti-Sumo 2+3 antibody - ab75229 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Sumo 2+3 antibody (ab75229) at 1/500 dilutionLane 1 : extracts from HeLa cellsLane 2 : extracts from HeLa cells with Cl peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Sumo 2+3 antibody [8A2] - ChIP Grade - ab81371 from Abcam

Prices $401.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8A2
Anti-Sumo 2+3 antibody [8A2] - ChIP Grade (ab81371) at 1/2000 dilution + HeLa cell lysate

Anti-Sumo 2+3 antibody [EPR300(2)] - ab109196 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR300(2)
All lanes : Anti-Sumo 2+3 antibody [EPR300(2)] (ab109196) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Jurkat cell lysateLysates/proteins at 10 µg per lane.

Anti-Sumo 2+3 antibody [EPR4602] - ab109005 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4602
All lanes : Anti-Sumo 2+3 antibody [EPR4602] (ab109005) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Jurkat cell lysateLane 3 : 293T cell lysateLane 4 : SW480 cell lysateLane 5 : HL60 cell lysateLysates/proteins at 10 µg per lane.

Anti-Sumo 2+3 antibody [EPR4602] (Alexa Fluor® 488) - ab196330 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4602
ab196330 staining Sumo 2+3 in SW480 cells. The cells were fixed with 4% formaldehyde (10 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab196330 at a 1/100 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at a 1/250 dilution (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-Sumo 2+3 antibody [EPR4602] (Alexa Fluor® 647) - ab196578 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4602
ab196578 staining Sumo 2+3 in SW480 cells. The cells were fixed with 4% formaldehyde (10 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab196578 at a 1/100 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at a 1/250 dilution (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-Sumo 2+3 antibody [SM23/496] - ab190757 from Abcam

Prices $379.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone SM23/496
Anti-Sumo 2+3 antibody [SM23/496] (ab190757) at 1 µg/ml + HeLa cell lysate

Anti-Sumo 3 antibody - ab124401 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Sumo 3 antibody (ab124401) at 1/500 dilution + C33A cell lysate

Anti-Sumo 3 antibody - ab34661 from Abcam

Prices $384.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Sumo 3 antibody (ab34661) at 1/1000 dilution (5% non-fat dry milk in TTBS)Lane 1 : Human GFP SUMO 3 at 1 µg with blocked for 1 hour with 5% non-fat dry milk in TTBSLane 2 : Human GFP SUMO 3 at 3 µg with blocked for 1 hour with 5% non-fat dry milk in TTBSLane 3 : Human GFP SUMO 3 at 5 µg with blocked for 1 hour with 5% non-fat dry milk in TTBSLane 4 : Human GFP SUMO 3 at 10 µg with blocked for 1 hour with 5% non-fat dry milk in TTBSSecondaryDonkey anti rabbit IgG at 1/1000 dilution

Anti-Sumo 3 antibody - ab43747 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-Sumo 3 antibody (ab43747) at 1/1000 dilutionLane 1 : Total protein extract from E coli with ~50ng to 100 ng of a GST fusion protein of an irrelevant antigenLane 2 : Total protein extract from E coli with ~50ng to 500ng of the GST fusion protein of the antigenLysates/proteins at 20 µg per lane.SecondaryRabbit anti-mouse IgG + IgM, (H+L) conjugated to horseradish peroxidase at 1/5000 dilution

Anti-Sumo 3 antibody - ab85442 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Sumo 3 antibody (ab85442) at 1 µg/ml (in 5% skim milk / PBS buffer) + MCF7 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Sumo 3 antibody - ab56187 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Sumo 3 antibody [76AT630.91.31] - ab38670 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 76AT630.91.31

Anti-Sumo 3 antibody [MM0923-14V22] - ab201594 from Abcam

Prices $359.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone MM0923-14V22

Anti-SUMO3 Antibody (AP) - LS-C283227 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
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