SUMO3
| Gene Symbol | SUMO3 |
|---|---|
| Entrez Gene | 6612 |
| Alt Symbol | SMT3A, SMT3H1, SUMO-3, Smt3B |
| Species | Human |
| Gene Type | protein-coding |
| Description | small ubiquitin-like modifier 3 |
| Other Description | SMT3 suppressor of mif two 3 homolog 1|SMT3 suppressor of mif two 3 homolog 3|small ubiquitin-related modifier 3|ubiquitin-like protein SMT3B |
| Swissprots | P55854 Q6FGD4 B4DUW4 Q9BWR4 Q53HI9 B2R5X4 |
| Accessions | EAX09390 EAX09391 EAX09392 EAX09393 P55854 AK222591 BAD96311 AK300822 BAG62476 AK312350 BAG35271 BC000036 AAH00036 BC008420 AAH08420 BT007008 AAP35654 CR542173 CAG46970 CR542188 CAG46985 X99584 CAA67896 NM_001286416 NP_001273345 NM_006936 NP_008867 |
| Function | Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678}. |
| Subcellular Location | Cytoplasm. Nucleus. Nucleus, PML body {ECO:0000250}. |
| Tissue Specificity | Expressed predominantly in liver. {ECO:0000269|PubMed:15487983}. |
| Top Pathways | RNA transport |
SUMO-3 CRISPR/Cas9 KO Plasmid (h) - sc-400788 from Santa Cruz Biotechnology
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SUMO-3 HDR Plasmid (h) - sc-400788-HDR from Santa Cruz Biotechnology
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SUMO-3 Double Nickase Plasmid (h) - sc-400788-NIC from Santa Cruz Biotechnology
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SUMO-3 Double Nickase Plasmid (h2) - sc-400788-NIC-2 from Santa Cruz Biotechnology
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SUMO-3 CRISPR Activation Plasmid (h) - sc-400788-ACT from Santa Cruz Biotechnology
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SUMO-3 CRISPR Activation Plasmid (h2) - sc-400788-ACT-2 from Santa Cruz Biotechnology
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SUMO-3 Lentiviral Activation Particles (h) - sc-400788-LAC from Santa Cruz Biotechnology
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SUMO-3 Lentiviral Activation Particles (h2) - sc-400788-LAC-2 from Santa Cruz Biotechnology
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SUMO-2/3 siRNA (h) - sc-37167 from Santa Cruz Biotechnology
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SUMO-2/3 shRNA Plasmid (h) - sc-37167-SH from Santa Cruz Biotechnology
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SUMO-2/3 shRNA (h) Lentiviral Particles - sc-37167-V from Santa Cruz Biotechnology
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SUMO-2 siRNA (h) - sc-41081 from Santa Cruz Biotechnology
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SUMO-2 siRNA Plasmid (h) - sc-41081-SH from Santa Cruz Biotechnology
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SUMO-2 shRNA (h) Lentiviral Particles - sc-41081-V from Santa Cruz Biotechnology
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SUMO3 RNAi - H00006612-R01 from Novus Biologicals
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MISSION® esiRNA - EHU051341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20835 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20835 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13107 from Sigma-Aldrich
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SUMO3 siRNA (Human) - CRH4495 from Cohesion Biosciences
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SUMO3 - MBS8238680 from MyBioSource
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SUMO-3 CRISPR/Cas9 KO Plasmid (h2) - sc-400788-KO-2 from Santa Cruz Biotechnology
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SUMO-3 HDR Plasmid (h2) - sc-400788-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human SUMO3 (NM_006936.2) - SHH420928 from Creative biogene
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shRNA set against Human SUMO3(NM_006936.2) - SHL048032 from Creative biogene
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