EXOSC5

Gene Symbol	EXOSC5
Entrez Gene	56915
Alt Symbol	RRP41B, RRP46, Rrp46p, hRrp46p, p12B
Species	Human
Gene Type	protein-coding
Description	exosome component 5
Other Description	chronic myelogenous leukemia tumor antigen 28|exosome complex component RRP46|exosome complex exonuclease RRP46|exosome component Rrp46|ribosomal RNA-processing protein 46
Swissprots	Q8NG16 Q96I89 Q9NQT4 Q32Q81
Accessions	EAW57038 Q9NQT4 AF281134 AAF82135 AF285785 AAM75154 AK314941 BAG37447 BC007742 AAH07742 BC107696 AAI07697 BU683254 JF432476 ADZ15693 NM_020158 NP_064543
Function	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}.
Tissue Specificity	Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Exosome complex component RRP46 (EXOSC5), Human, ELISA Kit - CSB-EL007893HU from ARP American Research Products Category ELISA Kit Prices $615.00, $815.00 Sizes 48 t, 96 t

EXOSC5 (Human) IP-WB Antibody Pair - H00056915-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

exosome component 5, ELISA Kit - MBS9336213 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/ml. Range 3.12 ng/ml - 100 ng/ml.

Human EXOSC5 ELISA Kit - E013850 from Biobool Category ELISA Kit Sensitivity 1.0 ng/ml.

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9375244 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9372664 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9374030 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9371559 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9375518 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0ng/ml Range 3.12ng/ml-100ng/ml

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9370358 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9371190 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9378224 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9376310 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9374890 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9378231 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9371806 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9377971 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9373264 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9378507 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9379065 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9376810 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9370939 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9372379 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9380034 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Exosome Complex Component RRP46 (EXOSC5), ELISA Kit - MBS9376037 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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