EXOSC5

Gene Symbol	EXOSC5
Entrez Gene	56915
Alt Symbol	RRP41B, RRP46, Rrp46p, hRrp46p, p12B
Species	Human
Gene Type	protein-coding
Description	exosome component 5
Other Description	chronic myelogenous leukemia tumor antigen 28|exosome complex component RRP46|exosome complex exonuclease RRP46|exosome component Rrp46|ribosomal RNA-processing protein 46
Swissprots	Q8NG16 Q96I89 Q9NQT4 Q32Q81
Accessions	EAW57038 Q9NQT4 AF281134 AAF82135 AF285785 AAM75154 AK314941 BAG37447 BC007742 AAH07742 BC107696 AAI07697 BU683254 JF432476 ADZ15693 NM_020158 NP_064543
Function	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}.
Tissue Specificity	Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EXOSC5 full length protein - ab124595 from Abcam Category Protein Source E. coli Species Human

Exosome component 5 Partial Recombinant Protein - H00056915-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Exosome component 5 Recombinant Protein - H00056915-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Exosome component 5 Protein - NBP1-99063 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human EXOSC5 protein - orb168318 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Source E.coli

EXOSC5 protein (His tag) - 80R-2201 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

EXOSC5 (1-235, His-tag) - AR50283PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

EXOSC5 (1-235, His-tag) - AR50283PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

EXOSC5 - H00056915-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EXOSC5 - H00056915-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EXOSC5 - H00056915-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EXOSC5 - H00056915-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EXOSC5, 1-235aa, Human, His tag, E.coli - 01-P1458 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

EXOSC5 fusion protein - Ag8159 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

EXOSC5 fusion protein - Ag8098 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Exosome Component 5 Protein - BP001968-PRO-1059 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 25 µg, 1 mg Species Human

Recombinant Human EXOSC5, His-tagged - EXOSC5-28337TH from Creative Biomart Category Protein Source E. coli

Recombinant Human EXOSC5, His-tagged - EXOSC5-12598H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Exosome complex component RRP46(EXOSC5) - CSB-YP878857HU CSB-EP878857HU CSB-BP878857HU CSB-MP878857HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EXOSC5, 1-235aa, Human, His tag, E.coli - ATGP1458 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

EXOSC5 - TP310665 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Exosome component 5 Protein - NBP2-33677PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

Exosome Component 5 Protein (Recombinant) - abx260873 from Abbexa Category Protein

EXOSC5 Peptide, Human - M34GP05145H from Creative Peptides Category Peptide Source Synthetic. Species Human

EXOSC5 - PAT-81498-1 from Nordic BioSite Category Protein Species Human

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