| Gene Symbol |
EXOSC5
|
| Entrez Gene |
56915
|
| Alt Symbol |
RRP41B, RRP46, Rrp46p, hRrp46p, p12B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
exosome component 5
|
| Other Description |
chronic myelogenous leukemia tumor antigen 28|exosome complex component RRP46|exosome complex exonuclease RRP46|exosome component Rrp46|ribosomal RNA-processing protein 46
|
| Swissprots |
Q8NG16 Q96I89 Q9NQT4 Q32Q81
|
| Accessions |
EAW57038 Q9NQT4 AF281134 AAF82135 AF285785 AAM75154 AK314941 BAG37447 BC007742 AAH07742 BC107696 AAI07697 BU683254 JF432476 ADZ15693 NM_020158 NP_064543
|
| Function |
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}.
|
| Tissue Specificity |
Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis.
|
| Top Pathways |
RNA degradation
|