| Gene Symbol | EXOSC5 |
|---|---|
| Entrez Gene | 56915 |
| Alt Symbol | RRP41B, RRP46, Rrp46p, hRrp46p, p12B |
| Species | Human |
| Gene Type | protein-coding |
| Description | exosome component 5 |
| Other Description | chronic myelogenous leukemia tumor antigen 28|exosome complex component RRP46|exosome complex exonuclease RRP46|exosome component Rrp46|ribosomal RNA-processing protein 46 |
| Swissprots | Q8NG16 Q96I89 Q9NQT4 Q32Q81 |
| Accessions | EAW57038 Q9NQT4 AF281134 AAF82135 AF285785 AAM75154 AK314941 BAG37447 BC007742 AAH07742 BC107696 AAI07697 BU683254 JF432476 ADZ15693 NM_020158 NP_064543 |
| Function | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways |
| Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}. |
| Tissue Specificity | Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis. |
| Top Pathways | RNA degradation |
EXOSC5 CRISPR/Cas9 KO Plasmid (h) - sc-412728 from Santa Cruz Biotechnology
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EXOSC5 HDR Plasmid (h) - sc-412728-HDR from Santa Cruz Biotechnology
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EXOSC5 Double Nickase Plasmid (h) - sc-412728-NIC from Santa Cruz Biotechnology
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EXOSC5 Double Nickase Plasmid (h2) - sc-412728-NIC-2 from Santa Cruz Biotechnology
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EXOSC5 CRISPR Activation Plasmid (h) - sc-412728-ACT from Santa Cruz Biotechnology
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EXOSC5 CRISPR Activation Plasmid (h2) - sc-412728-ACT-2 from Santa Cruz Biotechnology
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EXOSC5 Lentiviral Activation Particles (h) - sc-412728-LAC from Santa Cruz Biotechnology
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EXOSC5 Lentiviral Activation Particles (h2) - sc-412728-LAC-2 from Santa Cruz Biotechnology
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EXOSC5 siRNA (h) - sc-97360 from Santa Cruz Biotechnology
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EXOSC5 shRNA Plasmid (h) - sc-97360-SH from Santa Cruz Biotechnology
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EXOSC5 shRNA (h) Lentiviral Particles - sc-97360-V from Santa Cruz Biotechnology
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Exosome component 5 RNAi - H00056915-R01 from Novus Biologicals
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MISSION® esiRNA - EHU041641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8050 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8050 from Sigma-Aldrich
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EXOSC5 siRNA (Human) - CRJ1219 from Cohesion Biosciences
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EXOSC5 - MBS8208983 from MyBioSource
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shRNA set against Human EXOSC5 (NM_020158.3) - SHH288129 from Creative biogene
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Human EXOSC5 siRNA - orb271720 from Biorbyt
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EXOSC5 shRNA Plasmid (Human) - CHJ1219 from Cohesion Biosciences
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EXOSC5 miRNA 3'UTR clone - MiUTR1H-03348 from Creative biogene
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