EXOSC5

Gene Symbol EXOSC5
Entrez Gene 56915
Alt Symbol RRP41B, RRP46, Rrp46p, hRrp46p, p12B
Species Human
Gene Type protein-coding
Description exosome component 5
Other Description chronic myelogenous leukemia tumor antigen 28|exosome complex component RRP46|exosome complex exonuclease RRP46|exosome component Rrp46|ribosomal RNA-processing protein 46
Swissprots Q8NG16 Q96I89 Q9NQT4 Q32Q81
Accessions EAW57038 Q9NQT4 AF281134 AAF82135 AF285785 AAM75154 AK314941 BAG37447 BC007742 AAH07742 BC107696 AAI07697 BU683254 JF432476 ADZ15693 NM_020158 NP_064543
Function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:11812149}. Cytoplasm {ECO:0000305|PubMed:11812149}. Nucleus {ECO:0000305|PubMed:11812149}.
Tissue Specificity Highly expressed in a variety of hematopoietic and epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis.
Top Pathways RNA degradation

EXOSC5 (F-14) - sc-131153 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

EXOSC5 (T-12) - sc-131154 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EXOSC5 (T-12): sc-131154. Western blot analysis of EXOSC5 expression in human kidney tissue extract.

Anti-EXOSC5 antibody - ab69699 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-EXOSC5 antibody (ab69699) at 1/500 dilution + human kidney lysate at 25 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-EXOSC5 antibody - ab154718 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of paraformaldehyde-fixed HeLa cells labeling EXOSC5 with ab154718 at 1/500 dilution (Green). Alpha-tubulin filaments were labeled red.

Anti-EXOSC5 antibody - ab168804 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunoprecipitation analysis of whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. 1) ab168804 (6 µg/mg lysate). 2) A rabbit anti-EXOSC5 antibody immunoprecipitated EXOSC5. 3) Control IgG. For blotting ab168804 was used at 1 µg/ml. Detection by chemiluminescence with an exposure time of 10 seconds.

Anti-EXOSC5 Antibody - LS-C310296 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EXOSC5 Antibody - LS-C307942 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-EXOSC5 Antibody (N-Terminus) - LS-C345411 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of EXOS5 Antibody with human 721_B Whole Cell lysate.

Anti-EXOSC5 Antibody (clone 1E11) - LS-C139344 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E11
Western blot of EXOSC5 expression in transfected 293T cell line by EXOSC5 monoclonal antibody (M05), clone 1E11.

Anti-EXOSC5 Antibody (aa1-50) - LS-C290533 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EXOSC5 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-EXOSC5 antibody used for IP at 6 ug/mg lysate. EXOSC5 was also immunoprecipitated by rabbit anti-EXOSC5 antibody BL14010. For blotting immunoprecipitated EXOSC5, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.

Exosome component 5 Antibody - NBP2-14952 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: Exosome component 5 Antibody [NBP2-14952] - Paraformaldehyde-fixed HeLa, using EXOSC5 antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with an alpha Tubulin antibody (Red) at 1:2000.

Exosome component 5 Antibody - H00056915-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Exosome component 5 Antibody [H00056915-B01P] - Analysis of EXOSC5 expression in human kidney.

Exosome component 5 Antibody - NBP2-33677 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Exosome component 5 Antibody [NBP2-33677] - Staining of human bone marrow shows strong cytoplasmic positivity in hematopoietic cells.

Exosome component 5 Antibody - NBP2-22241 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Exosome component 5 Antibody (6G11) - H00056915-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6G11

Exosome component 5 Antibody (1E11) - H00056915-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E11
Western Blot: Exosome component 5 Antibody (1E11) [H00056915-M05] - Analysis of EXOSC5 expression in transfected 293T cell line by EXOSC5 monoclonal antibody (M05), clone 1E11. Lane 1: EXOSC5 transfected lysatE (25.3 KDa). Lane 2: Non-transfected lysate.

Exosome component 5 Antibody - H00056915-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Exosome component 5 Antibody (2E7) - H00056915-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E7
Immunocytochemistry/Immunofluorescence: Exosome component 5 Antibody (2E7) [H00056915-M03] - Analysis of monoclonal antibody to EXOSC5 on HeLa cell. Antibody concentration 10 ug/ml

Anti-EXOSC5 (N-terminal) antibody produced in rabbit - SAB4200439 from Sigma-Aldrich

Prices $337.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>HeLa cells were fixed and permeabilized with 4% paraformaldehyde followed by 0.5% Triton<SUP>™</SUP> X-100. Fixed cells were stained with 2 μg/mL Rabbit Anti-EXOSC5 (N-Terminal) (<B>Cat. No. SAB4200439</B>). The antibody was developed using Goat Anti-Rabbit IgG, Cy3<SUP>™</SUP> conjugate. Cells were counterstained with DAPI (blue) to stain nuclei.

Anti-EXOSC5 (C-terminal) antibody produced in rabbit - SAB4200438 from Sigma-Aldrich

Prices $337.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>HeLa cells were fixed and permeabilized with 4% paraformaldehyde followed by 0.5% Triton<SUP>™</SUP> X-100. Fixed cells were stained with 5 μg/mL Rabbit Anti-EXOSC5 (C-Terminal) (<B>Cat. No. SAB4200438</B>). The antibody was developed using Goat Anti-Rabbit IgG, Cy3<SUP>™</SUP> conjugate. Cells were counterstained with DAPI (blue) to stain nuclei.

Anti-EXOSC5 antibody produced in mouse - SAB1407754 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-EXOSC5: <B>Cat. No. SAB1407754</B>: Antibody concentration: 10 μg/mL using HeLa cell.

Monoclonal Anti-EXOSC5, (N-terminal) antibody produced in mouse - SAB1405196 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E11
<B>Immunoblotting</B><BR/>Monoclonal Anti-EXOSC5: <B>Cat. No. SAB1405196</B>: Antibody concentration: 1 μg/mL. Specific band of ~37.1 kDa using immunogen protein lysate.

Monoclonal Anti-EXOSC5 antibody produced in mouse - WH0056915M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6G11
<B>Sandwich ELISA</B><BR/>Monoclonal Anti-EXOSC5, <B>Cat. No. WH0056915M1</B>: the detection limit for recombinant GST tagged EXOSC5 is approximately 0.3ng/mL.

EXOS5 Antibody - N-terminal region (ARP40939_P050) - ARP40939_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

EXOSC5-Antibody-monoclonal-M01 - AT1968a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6G11
Immunofluorescence of monoclonal antibody to EXOSC5 on HeLa cell . [antibody concentration 10 ug/ml]
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