RIPK3

Gene Symbol	RIPK3
Entrez Gene	11035
Alt Symbol	RIP3
Species	Human
Gene Type	protein-coding
Description	receptor-interacting serine-threonine kinase 3
Other Description	RIP-3|RIP-like protein kinase 3|receptor interacting protein 3|receptor-interacting protein 3|receptor-interacting serine/threonine-protein kinase 3
Swissprots	C4AM87 Q5J795 B4DJL9 Q5J796 Q9Y572 Q6P5Y1
Accessions	EAW66021 EAW66022 Q9Y572 AF156884 AAD39005 AK075275 AK296140 BAG58881 AK296309 BAG59007 AY453693 AAS16359 AY494982 AAS75516 AY494983 AAS75517 BC041668 BC062584 AAH62584 BE676675 DB274842 NM_006871 NP_006862
Function	Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. {ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:22265413}. Cell membrane {ECO:0000250}. Mitochondrion {ECO:0000305}.
Tissue Specificity	Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. {ECO:0000269|PubMed:15896315}.
Top Pathways	Cytosolic DNA-sensing pathway, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat RIPK3 / RIP3 ELISA Kit (Sandwich ELISA) - LS-F9519 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.058 ng/ml Range 0.156-10 ng/ml

Rat RIPK3 / RIP3 ELISA Kit (Sandwich ELISA) - LS-F12504 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Receptor-interacting serine/threonine-protein kinase 3, RIPK3, Human, ELISA Kit - E11168h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t

Receptor Interacting Serine Threonine Kinase 3 (RIPK3), ELISA Kit - MBS2025051 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.058ng/mL Range 0.156-10ng/mL

Receptor Interacting Serine Threonine Kinase 3 (RIPK3), ELISA Kit - MBS2000291 from MyBioSource Category ELISA Kit Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.058ng/mL. Range 0.156-10ng/mL

Receptor Interacting Serine Threonine Kinase 3 (RIPK3), ELISA Kit - MBS2024867 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.122ng/mL. Range 0.313-20ng/mL

receptor-interacting serine-threonine kinase 3, ELISA Kit - MBS926196 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml.

ELISA Kit for Receptor Interacting Serine Threonine Kinase 3 (RIPK3) - SEE639Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.122ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Receptor Interacting Serine Threonine Kinase 3 (RIPK3) - SEE639Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.119ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Receptor Interacting Serine Threonine Kinase 3 (RIPK3) - SEE639Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Receptor-interacting serine/threonine-protein kinase 3(RIPK3) ELISA kit - CSB-EL019737HU from Cusabio Category ELISA Kit Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Human RIPK3 / RIP3 ELISA Kit (Sandwich ELISA) - LS-F16069 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Mouse RIPK3 / RIP3 ELISA Kit (Sandwich ELISA) - LS-F16068 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Human RIPK3 / RIP3 ELISA Kit (Sandwich ELISA) - LS-F25465 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.122 ng/ml Range 0.156-10 ng/ml

Mouse RIPK3 / RIP3 ELISA Kit (Sandwich ELISA) - LS-F25466 from LifeSpan Bioscience Category ELISA Kit Prices $800.00 Sizes 1 plate Sensitivity 0.119 ng/ml Range 0.156-10 ng/ml

Human RIPK3 ELISA Kit - E033009 from Biobool Category ELISA Kit Sensitivity Typically less than 0.122ng/mL.

RIPK3 ELISA Kit (Human) (OKCD02850) - OKCD02850 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 20 ng Sensitivity 0.122 ng/mL Range 0.312-20 ng/mL

Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3), ELISA Kit - MBS9352660 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3), ELISA Kit - MBS9361900 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3), ELISA Kit - MBS9363846 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3), ELISA Kit - MBS9367514 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3), ELISA Kit - MBS9352160 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3), ELISA Kit - MBS9365730 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3), ELISA Kit - MBS9349368 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3), ELISA Kit - MBS9362776 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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