RIPK3

Gene Symbol RIPK3
Entrez Gene 11035
Alt Symbol RIP3
Species Human
Gene Type protein-coding
Description receptor-interacting serine-threonine kinase 3
Other Description RIP-3|RIP-like protein kinase 3|receptor interacting protein 3|receptor-interacting protein 3|receptor-interacting serine/threonine-protein kinase 3
Swissprots C4AM87 Q5J795 B4DJL9 Q5J796 Q9Y572 Q6P5Y1
Accessions EAW66021 EAW66022 Q9Y572 AF156884 AAD39005 AK075275 AK296140 BAG58881 AK296309 BAG59007 AY453693 AAS16359 AY494982 AAS75516 AY494983 AAS75517 BC041668 BC062584 AAH62584 BE676675 DB274842 NM_006871 NP_006862
Function Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. {ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:22265413}. Cell membrane {ECO:0000250}. Mitochondrion {ECO:0000305}.
Tissue Specificity Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. {ECO:0000269|PubMed:15896315}.
Top Pathways Cytosolic DNA-sensing pathway, TNF signaling pathway

RIP3 CRISPR/Cas9 KO Plasmid (h) - sc-401008 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP3 HDR Plasmid (h) - sc-401008-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP3 Double Nickase Plasmid (h) - sc-401008-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP3 Double Nickase Plasmid (h2) - sc-401008-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP3 CRISPR Activation Plasmid (h) - sc-401008-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP3 CRISPR Activation Plasmid (h2) - sc-401008-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP3 Lentiviral Activation Particles (h) - sc-401008-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP3 Lentiviral Activation Particles (h2) - sc-401008-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP3 siRNA (h) - sc-61482 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RIP3 shRNA Plasmid (h) - sc-61482-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RIP3 shRNA (h) Lentiviral Particles - sc-61482-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RIPK3/RIP3 RNAi - H00011035-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU058861 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1968 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1970 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1969 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2355 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2355 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00472 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00472

RIPK3 siRNA (Human) - CRH7541 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RIPK3 - MBS8211656 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RIPK3 (NM_006871.3) - SHH396020 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human RIPK3(NM_006871.3) - SHR182910 from Creative biogene

Category siRNA
Species Reactivities Human

Human RIPK3 siRNA - orb268043 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RIPK3 shRNA Plasmid (Human) - CHH7541 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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