| Gene Symbol |
RIPK3
|
| Entrez Gene |
11035
|
| Alt Symbol |
RIP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
receptor-interacting serine-threonine kinase 3
|
| Other Description |
RIP-3|RIP-like protein kinase 3|receptor interacting protein 3|receptor-interacting protein 3|receptor-interacting serine/threonine-protein kinase 3
|
| Swissprots |
C4AM87 Q5J795 B4DJL9 Q5J796 Q9Y572 Q6P5Y1
|
| Accessions |
EAW66021 EAW66022 Q9Y572 AF156884 AAD39005 AK075275 AK296140 BAG58881 AK296309 BAG59007 AY453693 AAS16359 AY494982 AAS75516 AY494983 AAS75517 BC041668 BC062584 AAH62584 BE676675 DB274842 NM_006871 NP_006862
|
| Function |
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. {ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:22265413}. Cell membrane {ECO:0000250}. Mitochondrion {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. {ECO:0000269|PubMed:15896315}.
|
| Top Pathways |
Cytosolic DNA-sensing pathway, TNF signaling pathway
|
![Western Blot: RIPK3 Overexpression Lysate (Adult Normal) [NBL1-15379] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RIPK3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/871_RIPK3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15379-img0002.jpg)