RIPK3

Gene Symbol	RIPK3
Entrez Gene	11035
Alt Symbol	RIP3
Species	Human
Gene Type	protein-coding
Description	receptor-interacting serine-threonine kinase 3
Other Description	RIP-3|RIP-like protein kinase 3|receptor interacting protein 3|receptor-interacting protein 3|receptor-interacting serine/threonine-protein kinase 3
Swissprots	C4AM87 Q5J795 B4DJL9 Q5J796 Q9Y572 Q6P5Y1
Accessions	EAW66021 EAW66022 Q9Y572 AF156884 AAD39005 AK075275 AK296140 BAG58881 AK296309 BAG59007 AY453693 AAS16359 AY494982 AAS75516 AY494983 AAS75517 BC041668 BC062584 AAH62584 BE676675 DB274842 NM_006871 NP_006862
Function	Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. {ECO:0000269|PubMed:19498109, ECO:0000269|PubMed:19524512, ECO:0000269|PubMed:19524513, ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:22265413}. Cell membrane {ECO:0000250}. Mitochondrion {ECO:0000305}.
Tissue Specificity	Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. {ECO:0000269|PubMed:15896315}.
Top Pathways	Cytosolic DNA-sensing pathway, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human RIP3 full length protein - ab125566 from Abcam Category Protein Prices $239.00, $1,845.00 Sizes 5 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Human RIP3 peptide - ab178834 from Abcam Category Peptide Species Human

Human RIP3 protein fragment - ab112398 from Abcam Category Protein Source Wheat germ Species Human

RIP3 peptide - ab8464 from Abcam Category Peptide

RIPK3 / RIP3 Antibody Blocking Peptide - LS-E3380 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RIPK3 / RIP3 Antibody Blocking Peptide - LS-E10615 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RIPK3 / RIP3 Antibody Blocking Peptide - LS-E8744 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RIPK3 / RIP3 Antibody Blocking Peptide - LS-E8745 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RIPK3 / RIP3 Antibody Blocking Peptide - LS-E11556 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RIPK3 / RIP3 Antibody Blocking Peptide - LS-E9289 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RIPK3/RIP3 Protein - H00011035-P01 from Novus Biologicals Category Protein Prices $305.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RIPK3/RIP3 Protein - H00011035-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RIPK3/RIP3 Peptide - P2842 from Novus Biologicals Category Peptide Species Human

RIPK3/RIP3 Peptide - P2349 from Novus Biologicals Category Peptide Species Human

RIPK3/RIP3 Peptide - P2348 from Novus Biologicals Category Peptide Species Human

RIPK3-Antibody-C-term-Blocking-Peptide - BP14554b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RIPK3-Antibody-Center-Blocking-Peptide - BP7184b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RIPK3-Antibody-N-term-Blocking-Peptide - BP7184a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RIPK3-Antibody-C-term-Blocking-Peptide - BP7819b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RIPK3 / RIP3 - H00011035-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

RIPK3 / RIP3 - H00011035-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RIPK3 / RIP3 - H00011035-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RIPK3 / RIP3 control peptide - AP10298CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

RIPK3 fusion protein - ag11759 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human RIPK3 - RIPK3-29985TH from Creative Biomart Category Protein Source Wheat germ

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