Gene Symbol | TAC4 |
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Entrez Gene | 255061 |
Alt Symbol | EK, HK-1, HK1, PPT-C |
Species | Human |
Gene Type | protein-coding |
Description | tachykinin 4 (hemokinin) |
Other Description | endokinin|preprotachykinin-C|tachykinin-4 |
Swissprots | Q86UU8 Q6ECK8 Q8IWZ7 Q86UU6 Q2M2P1 Q86UU7 Q86UU9 |
Accessions | EAW94657 Q86UU9 AF515828 AAP30874 AF515829 AAP30875 AF515830 AAP30876 AF515831 AAP30877 AF521560 AAN77128 AY471574 AAS46596 BC100840 AAI00841 BC100841 BC100842 AAI00843 BC100843 AAI00844 BC111857 BC111858 NM_001077503 NP_001070971 NM_001077504 NP_001070972 NM_001077505 NP_001070973 NM_001077506 NP_001070974 NM_170685 NP_733786 |
Function | Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility. {ECO:0000269|PubMed:12716968, ECO:0000269|PubMed:17101218, ECO:0000269|PubMed:17437961, ECO:0000269|PubMed:17655832}. |
Subcellular Location | Secreted {ECO:0000305}. |
Tissue Specificity | Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta. {ECO:0000269|PubMed:12716968, ECO:0000269|PubMed:12788812}. |
Tachykinin 4 (C-14) - sc-47439 from Santa Cruz Biotechnology
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Tachykinin 4 (K-14) - sc-47440 from Santa Cruz Biotechnology
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Anti-Hemokinin 1 antibody - C-terminal - ab171318 from Abcam
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Anti-TAC4 Antibody (aa85-113, AP) - LS-C270920 from LifeSpan Bioscience
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Anti-TAC4 Antibody (aa85-113, APC) - LS-C270921 from LifeSpan Bioscience
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Anti-TAC4 Antibody (aa85-113, Biotin) - LS-C270923 from LifeSpan Bioscience
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Anti-TAC4 Antibody (aa85-113, FITC) - LS-C270924 from LifeSpan Bioscience
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Anti-TAC4 Antibody (aa85-113, Azide-free, HRP) - LS-C270925 from LifeSpan Bioscience
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Anti-TAC4 Antibody (aa85-113, PE) - LS-C270926 from LifeSpan Bioscience
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Anti-TAC4 Antibody (aa92-113) - LS-C325545 from LifeSpan Bioscience
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Anti-TAC4 Antibody (aa85-113) - LS-C161679 from LifeSpan Bioscience
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ANTI-TAC4 (C-TERM) antibody produced in rabbit - SAB1302037 from Sigma-Aldrich
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TAC4-Antibody-C-term - AP12845b from Abgent, a WuXi AppTec company
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TAC4 Antibody - C-terminal region (OAAB09132) - OAAB09132 from Aviva Systems Biology
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HK1 antibody - 10R-2226 from Fitzgerald
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HK1 antibody - 10R-2231 from Fitzgerald
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Hexokinase 1 antibody - 10R-10810 from Fitzgerald
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HK1 antibody - 70R-10230 from Fitzgerald
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TAC4 Antibody - abx027050 from Abbexa
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TAC4 (C-term) antibody - AP54138PU-N from Acris Antibodies
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TAC4 antibody (C-term) - STJ42673 from St John's Laboratory Ltd
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Anti-TAC4 (aa 92-113) polyclonal antibody - DPABH-09126 from Creative Diagnostics
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TAC4, Polyclonal Antibody - MBS645855 from MyBioSource
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TAC4, Polyclonal Antibody - MBS9201548 from MyBioSource
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Endokinin-C antibody - orb221400 from Biorbyt
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