| Gene Symbol | TAC4 |
|---|---|
| Entrez Gene | 255061 |
| Alt Symbol | EK, HK-1, HK1, PPT-C |
| Species | Human |
| Gene Type | protein-coding |
| Description | tachykinin 4 (hemokinin) |
| Other Description | endokinin|preprotachykinin-C|tachykinin-4 |
| Swissprots | Q86UU8 Q6ECK8 Q8IWZ7 Q86UU6 Q2M2P1 Q86UU7 Q86UU9 |
| Accessions | EAW94657 Q86UU9 AF515828 AAP30874 AF515829 AAP30875 AF515830 AAP30876 AF515831 AAP30877 AF521560 AAN77128 AY471574 AAS46596 BC100840 AAI00841 BC100841 BC100842 AAI00843 BC100843 AAI00844 BC111857 BC111858 NM_001077503 NP_001070971 NM_001077504 NP_001070972 NM_001077505 NP_001070973 NM_001077506 NP_001070974 NM_170685 NP_733786 |
| Function | Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility. {ECO:0000269|PubMed:12716968, ECO:0000269|PubMed:17101218, ECO:0000269|PubMed:17437961, ECO:0000269|PubMed:17655832}. |
| Subcellular Location | Secreted {ECO:0000305}. |
| Tissue Specificity | Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta. {ECO:0000269|PubMed:12716968, ECO:0000269|PubMed:12788812}. |
TAC4 - MBS1269854 from MyBioSource
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Human TAC4 cDNA clone(NM_170685.2) - CDFG010291 from Creative Biomart
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Human TAC4 cDNA clone(NM_001077503.1) - CDFH019146 from Creative Biomart
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Human TAC4 cDNA clone(NM_001077505.1) - CDFH019147 from Creative Biomart
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Human TAC4 cDNA clone(NM_001077506.1) - CDFH019148 from Creative Biomart
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Human TAC4 cDNA clone(NM_001077504.1) - CDFH019149 from Creative Biomart
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Human TAC4 ORF Clone(NM_001077503.1) - CDCL177739 from Creative Biomart
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Human TAC4 ORF Clone(NM_170685.2) - CDCR321142 from Creative Biomart
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Human TAC4 ORF Clone(NM_170685.2) - CDCR321143 from Creative Biomart
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Human TAC4 ORF Clone(NM_001077503.1) - CDCR345052 from Creative Biomart
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Human TAC4 ORF Clone(NM_001077503.1) - CDCR345053 from Creative Biomart
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Human TAC4 ORF Clone(NM_001077504.1) - CDCR345054 from Creative Biomart
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Human TAC4 ORF Clone(NM_001077504.1) - CDCR345055 from Creative Biomart
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Human TAC4 ORF Clone(NM_001077505.1) - CDCR345056 from Creative Biomart
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Human TAC4 ORF Clone(NM_001077505.1) - CDCR345057 from Creative Biomart
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Human TAC4 ORF Clone(NM_001077506.1) - CDCR345058 from Creative Biomart
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Human TAC4 ORF Clone(NM_001077506.1) - CDCR345059 from Creative Biomart
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human TAC4 ORF clone (NM_170685.2) - CDCH088400 from Creative biogene
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human TAC4 ORF clone (NM_001077503.1) - CDCH088402 from Creative biogene
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human TAC4 ORF clone (NM_001077504.1) - CDCH088404 from Creative biogene
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human TAC4 ORF clone (NM_001077505.1) - CDCH088406 from Creative biogene
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human TAC4 ORF clone (NM_001077506.1) - CDCH088408 from Creative biogene
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Human TAC4 ORF Clone (BC111858) - CDCS419694 from Creative biogene
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Human EK gene - orb91240 from Biorbyt
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Human TAC4 cDNA Clone(NM_170685.2) - CDFG010291 from Creative biogene
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