| Gene Symbol | TAC4 |
|---|---|
| Entrez Gene | 255061 |
| Alt Symbol | EK, HK-1, HK1, PPT-C |
| Species | Human |
| Gene Type | protein-coding |
| Description | tachykinin 4 (hemokinin) |
| Other Description | endokinin|preprotachykinin-C|tachykinin-4 |
| Swissprots | Q86UU8 Q6ECK8 Q8IWZ7 Q86UU6 Q2M2P1 Q86UU7 Q86UU9 |
| Accessions | EAW94657 Q86UU9 AF515828 AAP30874 AF515829 AAP30875 AF515830 AAP30876 AF515831 AAP30877 AF521560 AAN77128 AY471574 AAS46596 BC100840 AAI00841 BC100841 BC100842 AAI00843 BC100843 AAI00844 BC111857 BC111858 NM_001077503 NP_001070971 NM_001077504 NP_001070972 NM_001077505 NP_001070973 NM_001077506 NP_001070974 NM_170685 NP_733786 |
| Function | Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility. {ECO:0000269|PubMed:12716968, ECO:0000269|PubMed:17101218, ECO:0000269|PubMed:17437961, ECO:0000269|PubMed:17655832}. |
| Subcellular Location | Secreted {ECO:0000305}. |
| Tissue Specificity | Expressed at low levels in the uterus of both pregnant and non-pregnant women. Isoform 1 is found only in the adrenal gland and fetal liver. Isoform 2 is found in heart, liver, bone marrow, prostate, adrenal gland and testis. Isoform 3 and isoform 4 are expressed predominantly in adrenal gland and placenta. {ECO:0000269|PubMed:12716968, ECO:0000269|PubMed:12788812}. |
Tachykinin 4 CRISPR/Cas9 KO Plasmid (h) - sc-417158 from Santa Cruz Biotechnology
|
||||||||
Tachykinin 4 HDR Plasmid (h) - sc-417158-HDR from Santa Cruz Biotechnology
|
||||||||
Tachykinin 4 Double Nickase Plasmid (h) - sc-417158-NIC from Santa Cruz Biotechnology
|
||||||||
Tachykinin 4 Double Nickase Plasmid (h2) - sc-417158-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Tachykinin 4 CRISPR Activation Plasmid (h) - sc-417158-ACT from Santa Cruz Biotechnology
|
||||||||
Tachykinin 4 CRISPR Activation Plasmid (h2) - sc-417158-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Tachykinin 4 Lentiviral Activation Particles (h) - sc-417158-LAC from Santa Cruz Biotechnology
|
||||||||
Tachykinin 4 Lentiviral Activation Particles (h2) - sc-417158-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Tachykinin 4 siRNA (h) - sc-61635 from Santa Cruz Biotechnology
|
||||||||
Tachykinin 4 shRNA Plasmid (h) - sc-61635-SH from Santa Cruz Biotechnology
|
||||||||
Tachykinin 4 shRNA (h) Lentiviral Particles - sc-61635-V from Santa Cruz Biotechnology
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN20948 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20948 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR01997 from Sigma-Aldrich
|
||||||||
TAC4 siRNA (Human) - CRJ6706 from Cohesion Biosciences
|
||||||||
TAC4 - MBS8229735 from MyBioSource
|
||||||||
shRNA set against Human TAC4 (NM_170685.2) - SHH422404 from Creative biogene
|
||||||||
shRNA set against Human TAC4(NM_001077504.1) - SHL053116 from Creative biogene
|
||||||||
shRNA set against Human TAC4(NM_001077505.1) - SHL053472 from Creative biogene
|
||||||||
shRNA set against Human TAC4(NM_170685.2) - SHL053490 from Creative biogene
|
||||||||
shRNA set against Human TAC4(NM_001077506.1) - SHL053526 from Creative biogene
|
||||||||
shRNA set against Human TAC4(NM_001077503.1) - SHL053580 from Creative biogene
|
||||||||
Human TAC4 siRNA - orb277207 from Biorbyt
|
||||||||
TAC4 shRNA Plasmid (Human) - CHJ6706 from Cohesion Biosciences
|
||||||||
TAC4 miRNA 3'UTR clone - MiUTR1H-10139 from Creative biogene
|