SUPT16H

Gene Symbol	SUPT16H
Entrez Gene	11198
Alt Symbol	CDC68, FACTP140, SPT16, SPT16/CDC68
Species	Human
Gene Type	protein-coding
Description	suppressor of Ty 16 homolog (S. cerevisiae)
Other Description	FACT 140 kDa subunit|FACT complex subunit SPT16|chromatin-specific transcription elongation factor 140 kDa subunit|facilitates chromatin remodeling 140 kDa subunit|facilitates chromatin transcription complex subunit SPT16|hSPT16
Swissprots	Q9Y5B9 Q6PJM1 Q6P2F1 Q9NRX0 Q6GMT8
Accessions	EAW66386 EAW66387 Q9Y5B9 AF164924 AAF28231 AK001719 AK024072 AK091676 BC000565 AAH00565 BC012582 BC014046 AAH14046 BC064561 AAH64561 BC073849 AAH73849 BC111402 AAI11403 BP872403 XM_011536381 XP_011534683 NM_007192 NP_009123
Function	Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:10421373}. Chromosome {ECO:0000269|PubMed:10421373}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:10792464}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

FACT complex subunit SPT16, SUPT16H, ELISA Kit - MBS2602732 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 50 ng/ml-0.78 ng/ml

Human SUPT16H ELISA Kit - E014044 from Biobool Category ELISA Kit Sensitivity 0.1 ng/ml.

FACT complex subunit SPT16 (SUPT16H), ELISA Kit - MBS2610260 from MyBioSource Category ELISA Kit Prices $300.00, $475.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

FACT complex subunit SPT16, ELISA Kit - MBS2604887 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

FACT complex subunit SPT16, ELISA Kit - MBS2606467 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

FACT complex subunit SPT16, ELISA Kit - MBS2603681 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

FACT complex subunit SPT16, ELISA Kit - MBS2607477 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

FACT complex subunit SPT16, ELISA Kit - MBS2607348 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

FACT complex subunit SPT16, ELISA Kit - MBS2605288 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

FACT complex subunit SPT16, ELISA Kit - MBS2605030 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

FACT complex subunit SPT16, ELISA Kit - MBS2603180 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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