SUPT16H

Gene Symbol SUPT16H
Entrez Gene 11198
Alt Symbol CDC68, FACTP140, SPT16, SPT16/CDC68
Species Human
Gene Type protein-coding
Description suppressor of Ty 16 homolog (S. cerevisiae)
Other Description FACT 140 kDa subunit|FACT complex subunit SPT16|chromatin-specific transcription elongation factor 140 kDa subunit|facilitates chromatin remodeling 140 kDa subunit|facilitates chromatin transcription complex subunit SPT16|hSPT16
Swissprots Q9Y5B9 Q6PJM1 Q6P2F1 Q9NRX0 Q6GMT8
Accessions EAW66386 EAW66387 Q9Y5B9 AF164924 AAF28231 AK001719 AK024072 AK091676 BC000565 AAH00565 BC012582 BC014046 AAH14046 BC064561 AAH64561 BC073849 AAH73849 BC111402 AAI11403 BP872403 XM_011536381 XP_011534683 NM_007192 NP_009123
Function Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10421373}. Chromosome {ECO:0000269|PubMed:10421373}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:10792464}.

SPT16 CRISPR/Cas9 KO Plasmid (h) - sc-401268 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT16 HDR Plasmid (h) - sc-401268-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT16 Double Nickase Plasmid (h) - sc-401268-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT16 Double Nickase Plasmid (h2) - sc-401268-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT16 CRISPR Activation Plasmid (h) - sc-401268-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT16 CRISPR Activation Plasmid (h2) - sc-401268-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT16 Lentiviral Activation Particles (h) - sc-401268-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT16 Lentiviral Activation Particles (h2) - sc-401268-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT16 siRNA (h) - sc-37875 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPT16 shRNA Plasmid (h) - sc-37875-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPT16 shRNA (h) Lentiviral Particles - sc-37875-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SUPT16H RNAi - H00011198-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU039881 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2365 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08866 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08866

SUPT16H siRNA (Human) - CRH7675 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SUPT16H - MBS8205674 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Supt16h (NM_007192.3) - SHH420992 from Creative biogene

Category siRNA
Species Reactivities Human

SUPT16H shRNA Plasmid (Human) - CHH7675 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SUPT16H miRNA 3'UTR clone - MiUTR3H-07297 from Creative biogene

Species Reactivities Human
Search more