| Gene Symbol |
SUPT16H
|
| Entrez Gene |
11198
|
| Alt Symbol |
CDC68, FACTP140, SPT16, SPT16/CDC68
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppressor of Ty 16 homolog (S. cerevisiae)
|
| Other Description |
FACT 140 kDa subunit|FACT complex subunit SPT16|chromatin-specific transcription elongation factor 140 kDa subunit|facilitates chromatin remodeling 140 kDa subunit|facilitates chromatin transcription complex subunit SPT16|hSPT16
|
| Swissprots |
Q9Y5B9 Q6PJM1 Q6P2F1 Q9NRX0 Q6GMT8
|
| Accessions |
EAW66386 EAW66387 Q9Y5B9 AF164924 AAF28231 AK001719 AK024072 AK091676 BC000565 AAH00565 BC012582 BC014046 AAH14046 BC064561 AAH64561 BC073849 AAH73849 BC111402 AAI11403 BP872403 XM_011536381 XP_011534683 NM_007192 NP_009123
|
| Function |
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10421373}. Chromosome {ECO:0000269|PubMed:10421373}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10792464}.
|