SUPT16H

Gene Symbol	SUPT16H
Entrez Gene	11198
Alt Symbol	CDC68, FACTP140, SPT16, SPT16/CDC68
Species	Human
Gene Type	protein-coding
Description	suppressor of Ty 16 homolog (S. cerevisiae)
Other Description	FACT 140 kDa subunit|FACT complex subunit SPT16|chromatin-specific transcription elongation factor 140 kDa subunit|facilitates chromatin remodeling 140 kDa subunit|facilitates chromatin transcription complex subunit SPT16|hSPT16
Swissprots	Q9Y5B9 Q6PJM1 Q6P2F1 Q9NRX0 Q6GMT8
Accessions	EAW66386 EAW66387 Q9Y5B9 AF164924 AAF28231 AK001719 AK024072 AK091676 BC000565 AAH00565 BC012582 BC014046 AAH14046 BC064561 AAH64561 BC073849 AAH73849 BC111402 AAI11403 BP872403 XM_011536381 XP_011534683 NM_007192 NP_009123
Function	Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:10421373}. Chromosome {ECO:0000269|PubMed:10421373}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:10792464}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SUPT16H protein fragment - ab161347 from Abcam Category Protein Source Wheat germ Species Human

SUPT16H / FACTP140 Antibody Blocking Peptide - LS-E14021 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SUPT16H / FACTP140 Antibody Blocking Peptide - LS-E25980 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SUPT16H Protein - H00011198-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SUPT16H-Antibody-Center-Blocking-peptide - BP13844c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SUPT16H Blocking Peptide - 33R-1511 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SUPT16H Peptide - AC21-0807-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SUPT16H / FACT140 - H00011198-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SUPT16H / FACT140 - H00011198-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SUPT16H Peptide - 46-450P from ProSci Category Peptide Species Human

Recombinant Spt16 / FACT p140 protein - 31344 from ActiveMotif Category Protein Prices $370.00 Sizes 10 µg Source Baculovirus Species Human

SPT16 (S967) Peptide - BS2174P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

FACT/SUPT16H, Peptide - MBS425318 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Pig, Bovine

Recombinant Spt16 / FACT p140 protein , Sf9 cells , 10 ug - HM-PR10204 from Novatein Biosciences Category Protein Prices $435.50 Sizes 10 µg Source Sf9 cells

SUPT16H Recombinant Protein Antigen - NBP2-38607PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SUPT16H Blocking Peptide - abx061252 from Abbexa Category Peptide Species Human, Mouse, Rat

SUPT16H Peptide, Human - M34GP15413H from Creative Peptides Category Peptide Source Synthetic. Species Human

FACTP140 (838-845) - N07002 from Creative Peptides Category Peptide

SUPT16H Blocking Peptide - CBP5165 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

SUPT16H Immunizing peptide - orb16942 from Biorbyt Category Peptide

SUPT16H peptide - orb319311 from Biorbyt Category Peptide

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