SUPT16H

Gene Symbol SUPT16H
Entrez Gene 11198
Alt Symbol CDC68, FACTP140, SPT16, SPT16/CDC68
Species Human
Gene Type protein-coding
Description suppressor of Ty 16 homolog (S. cerevisiae)
Other Description FACT 140 kDa subunit|FACT complex subunit SPT16|chromatin-specific transcription elongation factor 140 kDa subunit|facilitates chromatin remodeling 140 kDa subunit|facilitates chromatin transcription complex subunit SPT16|hSPT16
Swissprots Q9Y5B9 Q6PJM1 Q6P2F1 Q9NRX0 Q6GMT8
Accessions EAW66386 EAW66387 Q9Y5B9 AF164924 AAF28231 AK001719 AK024072 AK091676 BC000565 AAH00565 BC012582 BC014046 AAH14046 BC064561 AAH64561 BC073849 AAH73849 BC111402 AAI11403 BP872403 XM_011536381 XP_011534683 NM_007192 NP_009123
Function Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). {ECO:0000269|PubMed:10912001, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:12934006, ECO:0000269|PubMed:16713563, ECO:0000269|PubMed:9489704, ECO:0000269|PubMed:9836642}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10421373}. Chromosome {ECO:0000269|PubMed:10421373}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:10792464}.

SPT16 (D7I2K) Rabbit mAb - 12191 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D7I2K
Western blot analysis of extracts from various cell lines using SPT16 (D7I2K) Rabbit mAb.

SPT16 (D-3) - sc-377028 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPT16 (D-3): sc-377028. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lower stomach tissue showing cytoplasmic, membrane and nuclear staining of glandular cells.

SPT16 (D-10) - sc-165988 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPT16 (D-10): sc-165988. Western blot analysis of SPT16 expression in K-562 (A), A-673 (B) and HeLa (C) nuclear extracts and MCP-5 whole cell lysate (D).

SPT16 (C-21) - sc-5915 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SPT16 (C-21): sc-5915. Western blot analysis of SPT16 expression in HeLa (A) and A-673 (B) nuclear extracts and UV-treated HeLa whole cell lysate (C).

SPT16 (A-1) - sc-165987 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPT16 (A-1): sc-165987. Western blot analysis of SPT16 expression in K-562 (A), A-673 (B) and HeLa (C) nuclear extracts and MCP-5 whole cell lysate (D).

SPT16 (8) - sc-136406 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PT16 (8): sc-136406. Western blot analysis of SPT16 expression in Jurkat whole cell lysate.

SPT16 (H-300) - sc-28734 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SPT16 (H-300): sc-28734. Immunofluorescence staining of methanol-fixed UV-treated HeLa cells showing nuclear localization.

SPT16 (H-4) - sc-165989 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPT16 (H-4): sc-165989. Western blot analysis of SPT16 expression in K-562 (A), A-673 (B) and HeLa (C) nuclear extracts and MCP-5 whole cell lysate (D).

SPT16 (N-17) - sc-5912 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SPT16 (N-17): sc-5912. Immunofluorescence staining of methanol-fixed UV-treated HeLa showing nuclear localization.

Anti-SUPT16H antibody - ab117081 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Testis (formalin-fixed, paraffin-embedded) stained with ab117081 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-SUPT16H antibody - ab62798 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-SUPT16H antibody (ab62798) at 0.1 µg/ml + HeLa cell lysate (35µg protein in RIPA buffer).

Anti-SUPT16H antibody - ab14466 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SUPT16H antibody - ab64961 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SUPT16H antibody (ab64961) at 1/500 dilutionLane 1 : HepG2 cell extractLane 2 : HepG2 cell extract with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-SUPT16H antibody - ab28359 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SUPT16H antibody - ab56855 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SUPT16H antibody - ab56857 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56857 SUPT16H antibody at 1ug/ml.

Anti-SUPT16H antibody [EPR3685] - ab108960 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3685
All lanes : Anti-SUPT16H antibody [EPR3685] (ab108960) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Jurkat cell lysateLane 3 : A549 cell lysateLysates/proteins at 10 µg per lane.

Anti-SUPT16H / FACTP140 Antibody - LS-C26775 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SUPT16H / FACTP140 Antibody (Ser967) - LS-C191993 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SUPT16H / FACTP140 Antibody (clone 1D4B) - LS-C189757 from LifeSpan Bioscience

Prices $325.00
Sizes 25 µg
Host Mouse
Clonality Monoclonal
Clone 1D4B

Anti-SUPT16H / FACTP140 Antibody (aa608-716, Azide-free) - LS-C328810 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-SUPT16H / FACTP140 Antibody (aa77-126) - LS-C31845 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-SUPT16H / FACTP140 Antibody (aa997-1047) - LS-C289228 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Spt16 by Western Blot. Samples: Whole cell lysate (5, 15 and 50 ug) from HeLa cells. Antibodies: Affinity purified rabbit anti-Spt16 antibody used at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-SUPT16H / FACTP140 Antibody (aa321-640) IHC-plus™ - LS-B753 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SUPT16H antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B753 concentration 20 ug/ml.

Anti-SUPT16H / FACTP140 Antibody (aa971-1020) - LS-C101717 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SUPT16H antibody LS-C101717 Western blot of 293T cell lysate.
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