IFNL2

Gene Symbol IFNL2
Entrez Gene 282616
Alt Symbol IL-28A, IL28A
Species Human
Gene Type protein-coding
Description interferon, lambda 2
Other Description IFN-lambda-2|cytokine Zcyto20|interferon lambda 2|interferon lambda-2|interferon-lambda 2|interleukin 28A (interferon, lambda 2)|interleukin-28A
Swissprots Q6VN55 Q8IWL7 Q8IZJ0 Q45KQ8
Accessions AAZ38827 CAI75182 CAJ41835 CAL33801 CAS97663 CAT02301 CBY45347 CBY45407 CDL78889 EAW56870 Q8IZJ0 AY129148 AAN28263 AY184373 AAN86126 AY336715 AAR24510 BC113581 AAI13582 BC113583 AAI13584 DQ126337 AAZ38828 XM_011526756 XP_011525058 NM_172138 NP_742150
Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
Subcellular Location Secreted {ECO:0000269|PubMed:12483210}.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

IL-28 (K-14) - sc-46375 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IL-28 (K-14): sc-46375. Western blot analysis of purified human IL-28.

IL-28 (K-12) - sc-46374 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IL-28/29 (FL-200) - sc-66933 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-28/29 (FL-200): sc-66933. Western blot analysis of human recombinant IL-28/29.

Anti-IL28 + IL29 [EPR14608] antibody - ab191426 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14608
Anti-IL28 + IL29 [EPR14608] antibody (ab191426) at 1/50000 dilution + IL28A recombinant protein at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugate at 1/1000 dilution

Anti-IL28A antibody - ab38570 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-IL28A antibody (ab38570) at 1/100 dilution + Mouse brain tissue lysate

Anti-IL28A antibody - ab109820 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-IL28A antibody (Biotin) - ab84239 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-IL28A antibody - C-terminal - ab190645 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-IL28A antibody - C-terminal (ab190645) at 1/500 dilution + MCF7 cell extract at 30 µg

Anti-IFNL2 / IL28A Antibody (aa61-92) - LS-C97857 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-IL28 Ctr-term antibody is used in Western blot to detect IL28 in mouse brain tissue lysate.

Anti-IFNL2 / IL28A Antibody (aa26-200) - LS-C314815 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IL28A.

Anti-IFNL2 / IL28A Antibody IHC-plus™ - LS-B7476 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-IL28A antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7476 concentration 5 ug/ml.

Anti-IFNL2 / IL28A Antibody (aa20-193, clone 11n112) - LS-C184832 from LifeSpan Bioscience

Prices $575.00
Sizes 500 µg
Host Rat
Clonality Monoclonal
Clone 11n112

Anti-IFNL2 / IL28A Antibody - LS-C314037 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IFNL2 / IL28A Antibody (Biotin) - LS-C104833 from LifeSpan Bioscience

Prices $285.00, $325.00
Sizes 25 µg, 50 µg
Host Rabbit
Clonality Polyclonal

IL-28A/IFN-lambda 2 Antibody [Unconjugated] - AF1587 from Novus Biologicals

Prices $99.00, $365.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Recombinant Human IL‑28A/IFN‑ lambda 2 (Catalog # 1587‑IL) reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the HepG2 human hepatocellular carcinoma cell line in a dose-dependent manner (orange line), as measured by crystal violet staining. Inhibition of EMCV activity elicited by Recombinant HumanIL‑28A/IFN‑ lambda 2 (0.1 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL‑28A/IFN‑ lambda 2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1587). The ND50 is typically 0.3-1.5 µg/mL.

IL-28A/IFN-lambda 2 Antibody (248526) [Unconjugated] - MAB1587 from Novus Biologicals

Prices $99.00, $269.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 248526
Recombinant HumanIL‑28A/IFN‑ lambda 2 (Catalog #1587‑IL) reduces the Encephalomyocarditis Virus (EMCV)-induced cytopathy in the HepG2 human hepatocellular carcinoma cell line in a dose-dependent manner (orange line). Inhibition of EMCV activity elicited by Recom­binant Human IL‑28A/IFN‑ lambda 2 (0.1 µg/mL) is neutralized (green line) by increasing concentrations of Mouse Anti‑Human IL‑28A/IFN‑ lambda 2 Monoclonal Antibody (Catalog # MAB1587). The ND50 is typically 0.25‑1.0 µg/mL.

IL-28A/IFN-lambda 2 Antibody (MM0400-6Z37) - NBP2-11705 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0400-6Z37

IL-28A/IFN-lambda 2 Antibody [Biotin] - BAF1587 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-IL28 (center) antibody produced in rabbit - SAB1300225 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-IL28 (Center) Antibody: <B>Cat. No. SAB1300225</B>: IL28 in human hepatocarcinoma tissue with Anti-IL28 (Center) Antibody at 40 μg/mL.

ANTI-IL28 (CENTER) antibody produced in rabbit - SAB1305142 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal

IL28-Antibody-Center - AP1708b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
The anti-IL28 Ctr-term Pab (Cat. #AP1708b) is used in Western blot to detect IL28 in mouse brain tissue lysate.

IL28A antibody [6Z37] - GTX52854 from GeneTex

Prices $319.00
Sizes 100 μg
Host Mouse
Clonality Monoclonal
Clone 6Z37

IL28 Antibody - middle region (OAAB12507) - OAAB12507 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Human IL-28A/IFN-lambda 2 Antibody - MAB15871 from R&D Systems

Prices $99.00, $269.00, $699.00
Sizes 25 µg, 100 µg, 500 µg
Host Mouse
Clone 248512

Human IL-28A/IFN-lambda 2 MAb (Clone 248512), Mouse IgG2B - MAB15871-SP from R&D Systems

Host Mouse
Clonality Monoclonal
Clone 248512
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