IFNL2

Gene Symbol	IFNL2
Entrez Gene	282616
Alt Symbol	IL-28A, IL28A
Species	Human
Gene Type	protein-coding
Description	interferon, lambda 2
Other Description	IFN-lambda-2|cytokine Zcyto20|interferon lambda 2|interferon lambda-2|interferon-lambda 2|interleukin 28A (interferon, lambda 2)|interleukin-28A
Swissprots	Q6VN55 Q8IWL7 Q8IZJ0 Q45KQ8
Accessions	AAZ38827 CAI75182 CAJ41835 CAL33801 CAS97663 CAT02301 CBY45347 CBY45407 CDL78889 EAW56870 Q8IZJ0 AY129148 AAN28263 AY184373 AAN86126 AY336715 AAR24510 BC113581 AAI13582 BC113583 AAI13584 DQ126337 AAZ38828 XM_011526756 XP_011525058 NM_172138 NP_742150
Function	Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
Subcellular Location	Secreted {ECO:0000269|PubMed:12483210}.
Top Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IL-28A (Interleukin-28A) Human ELISA Kit - ab100567 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 15 pg/ml Range 13.72 pg/ml - 10000 pg/ml

Human IFNL2 / IL28A ELISA Kit (Sandwich ELISA) - LS-F2796 from LifeSpan Bioscience Category ELISA Kit Prices $490.00 Sizes 1 plate Sensitivity 10 pg/ml Range 13.71-3333 pg/ml

Human IFNL2 / IL28A ELISA Kit (Sandwich ELISA) - LS-F4909 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 7.81 pg/ml Range 13.71-3333 pg/ml

Human IFNL2 / IL28A ELISA Kit (Sandwich ELISA) - LS-F645 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 13.71-3333 pg/ml

Human IFNL2 / IL28A ELISA Kit (Sandwich ELISA) - LS-F123 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 13.71 pg/ml Range 13.71-3333 pg/ml

Mouse IFNL2 / IL28A ELISA Kit (Sandwich ELISA) - LS-F8158 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 5.8 pg/ml Range 13.71-3333 pg/ml

Human IFNL2 / IL28A ELISA Kit (Sandwich ELISA) - LS-F11773 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 15.6 Range 13.71-3333 pg/ml

Mouse IFNL2 / IL28A ELISA Kit (Sandwich ELISA) - LS-F11774 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 31.2 Range 13.71-3333 pg/ml

Human IL-28A / IFN-λ ELISA Kit - RAB0291 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human IL-28A/IFN-lambda 2 DuoSet ELISA - DY1587 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 125.00 - 8,000 pg/mL

Human IL28A ELISA kit - 55R-1967 from Fitzgerald Category ELISA Kit Prices $435.00 Sizes 96 tests

IL-28A ELISA Kit (Human) : 96 Wells (OKAG00146) - OKAG00146 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 125 pg/mL Range 125-8,000 pg/mL

Human IL-28A ELISA Kit - abx056229 from Abbexa Category ELISA Kit

Interleukin 28A (IL28A), Human, ELISA Kit - SEB689Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 6.4pg/mL Range 15.6-1,000pg/mL

Interleukin 28A, IL-28A/IFN-_2, Human, ELISA Kit - CSB-E11708h from ARP American Research Products Category ELISA Kit Prices $295.00, $395.00, $396.00, $397.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7.8 pg/ml Range 31.25 pg/ml-2000 pg/ml

Interleukin-28A, IL28A, Human, ELISA Kit - E1689h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 15.6-1000 pg/mL

Interleukin 28A (IL28A), Human, CLIA Kit - SCB689Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 4.4pg/mL Range 15.6-1,000pg/mL

IL28A (Human) ELISA Kit - KA1736 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

IL28A ELISA Kit - KE00011 from Acris Antibodies Category ELISA Kit Prices $599.00 Sizes 1 kit Range 1 pg/ml

Human IL-28A ELISA - ELH-IL28A from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 15 pg/ml Range 15 pg/ml - 10000 pg/ml

Human IL28A ELISA Kit - KE00011 from Proteintech Group Category ELISA Kit Prices $599.00 Sizes 1 Sensitivity 1 pg/mL Range 7.8pg/mL-500pg/mL

IL-28A - MBS494996 from MyBioSource Category ELISA Kit Sensitivity < 10pg/ml Range 125pg/ml-8000pg/ml

IL-28A, ELISA Kit - MBS824735 from MyBioSource Category ELISA Kit Prices $470.00 Sizes 96 tests Sensitivity 10 pg/ml Range 125 pg/ml - 8000 pg/ml

IL-28A, ELISA Kit - MBS177330 from MyBioSource Category ELISA Kit Prices $390.00 Sizes 1x96 wells Sensitivity < 10pg/ml Range 125pg/ml-8000pg/ml

IL-28A (Human) OmniKine™ ELISA Kit - OK-0246 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range 125-8000 pg/ml

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