IFNL2
| Gene Symbol | IFNL2 |
|---|---|
| Entrez Gene | 282616 |
| Alt Symbol | IL-28A, IL28A |
| Species | Human |
| Gene Type | protein-coding |
| Description | interferon, lambda 2 |
| Other Description | IFN-lambda-2|cytokine Zcyto20|interferon lambda 2|interferon lambda-2|interferon-lambda 2|interleukin 28A (interferon, lambda 2)|interleukin-28A |
| Swissprots | Q6VN55 Q8IWL7 Q8IZJ0 Q45KQ8 |
| Accessions | AAZ38827 CAI75182 CAJ41835 CAL33801 CAS97663 CAT02301 CBY45347 CBY45407 CDL78889 EAW56870 Q8IZJ0 AY129148 AAN28263 AY184373 AAN86126 AY336715 AAR24510 BC113581 AAI13582 BC113583 AAI13584 DQ126337 AAZ38828 XM_011526756 XP_011525058 NM_172138 NP_742150 |
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express |
| Subcellular Location | Secreted {ECO:0000269|PubMed:12483210}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
Active human IL28A full length protein - ab50037 from Abcam
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Human IL28A full length protein - ab177716 from Abcam
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Human IL28A full length protein - ab194139 from Abcam
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IL28A protein fragment - ab50172 from Abcam
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IFNL2 / IL28A Antibody Blocking Peptide - LS-E4719 from LifeSpan Bioscience
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Recombinant Human IL28 Protein - NBP1-99427 from Novus Biologicals
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IL-28A/IFN-lambda 2 Recombinant Protein - P4174 from Novus Biologicals
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IL-28A/IFN-lambda 2 Peptide - P0622 from Novus Biologicals
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IL28-Antibody-Center-Blocking-peptide - BP1708b from Abgent, a WuXi AppTec company
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IL28A Recombinant Protein (Active) - GTX48237-PRO from GeneTex
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IL-28 recombinant protein - GTX65470 from GeneTex
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Recombinant Human IL-28A/IFN-lambda 2 - 1587-IL-025 from R&D Systems
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Recombinant Human IL-28A/IFN-lambda 2, CF - 1587-IL-025/CF from R&D Systems
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Recombinant Human IL-28A/IFN-lambda 2 (HEK293) - 8417-IL-025 from R&D Systems
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Recombinant Human IL-28A/IFN-lambda 2 (HEK293), CF - 8417-IL-025/CF from R&D Systems
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IL 28A Protein (OPPA01639) - OPPA01639 from Aviva Systems Biology
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Mouse IL 28A protein - orb168633 from Biorbyt
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Human IL-28A (His Tag) protein - orb232291 from Biorbyt
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Human IL 28A protein - orb168632 from Biorbyt
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Human IL 28A protein - orb80475 from Biorbyt
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IFN gamma 2 protein - 30R-AI150 from Fitzgerald
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IFNL2 protein (His tag) - 80R-3696 from Fitzgerald
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IL28 protein - 30R-2796 from Fitzgerald
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IL-28A Blocking Peptide - abx064093 from Abbexa
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Interleukin-28A / IL28A (26-200, His-tag) - AR51383PU-N from Acris Antibodies
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