| Gene Symbol | IFNL2 |
|---|---|
| Entrez Gene | 282616 |
| Alt Symbol | IL-28A, IL28A |
| Species | Human |
| Gene Type | protein-coding |
| Description | interferon, lambda 2 |
| Other Description | IFN-lambda-2|cytokine Zcyto20|interferon lambda 2|interferon lambda-2|interferon-lambda 2|interleukin 28A (interferon, lambda 2)|interleukin-28A |
| Swissprots | Q6VN55 Q8IWL7 Q8IZJ0 Q45KQ8 |
| Accessions | AAZ38827 CAI75182 CAJ41835 CAL33801 CAS97663 CAT02301 CBY45347 CBY45407 CDL78889 EAW56870 Q8IZJ0 AY129148 AAN28263 AY184373 AAN86126 AY336715 AAR24510 BC113581 AAI13582 BC113583 AAI13584 DQ126337 AAZ38828 XM_011526756 XP_011525058 NM_172138 NP_742150 |
| Function | Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express |
| Subcellular Location | Secreted {ECO:0000269|PubMed:12483210}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
IL-28A CRISPR/Cas9 KO Plasmid (h) - sc-405375 from Santa Cruz Biotechnology
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IL-28A HDR Plasmid (h) - sc-405375-HDR from Santa Cruz Biotechnology
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IL-28A Double Nickase Plasmid (h) - sc-405375-NIC from Santa Cruz Biotechnology
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IL-28A Double Nickase Plasmid (h2) - sc-405375-NIC-2 from Santa Cruz Biotechnology
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IL-28A CRISPR Activation Plasmid (h) - sc-405375-ACT from Santa Cruz Biotechnology
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IL-28A CRISPR Activation Plasmid (h2) - sc-405375-ACT-2 from Santa Cruz Biotechnology
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IL-28A Lentiviral Activation Particles (h) - sc-405375-LAC from Santa Cruz Biotechnology
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IL-28A Lentiviral Activation Particles (h2) - sc-405375-LAC-2 from Santa Cruz Biotechnology
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IL-28A siRNA (h) - sc-45664 from Santa Cruz Biotechnology
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IL-28A shRNA Plasmid (h) - sc-45664-SH from Santa Cruz Biotechnology
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IL-28A shRNA (h) Lentiviral Particles - sc-45664-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10619 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10619 from Sigma-Aldrich
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IFNL2 siRNA (Human) - CRJ6845 from Cohesion Biosciences
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IFNL2 - MBS8224346 from MyBioSource
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IL-28A CRISPR/Cas9 KO Plasmid (h2) - sc-405375-KO-2 from Santa Cruz Biotechnology
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IL-28A HDR Plasmid (h2) - sc-405375-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human IL28A (NM_172138.1) - SHH318825 from Creative biogene
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shRNA set against Human IL28A(NM_172138.1) - SHL172936 from Creative biogene
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IFNL2 shRNA Plasmid (Human) - CHJ6845 from Cohesion Biosciences
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IL28A miRNA 3'UTR clone - MiUTR1H-04914 from Creative biogene
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