| Gene Symbol |
IFNL2
|
| Entrez Gene |
282616
|
| Alt Symbol |
IL-28A, IL28A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interferon, lambda 2
|
| Other Description |
IFN-lambda-2|cytokine Zcyto20|interferon lambda 2|interferon lambda-2|interferon-lambda 2|interleukin 28A (interferon, lambda 2)|interleukin-28A
|
| Swissprots |
Q6VN55 Q8IWL7 Q8IZJ0 Q45KQ8
|
| Accessions |
AAZ38827 CAI75182 CAJ41835 CAL33801 CAS97663 CAT02301 CBY45347 CBY45407 CDL78889 EAW56870 Q8IZJ0 AY129148 AAN28263 AY184373 AAN86126 AY336715 AAR24510 BC113581 AAI13582 BC113583 AAI13584 DQ126337 AAZ38828 XM_011526756 XP_011525058 NM_172138 NP_742150
|
| Function |
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen express
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:12483210}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
|
