| Gene Symbol |
COMMD5
|
| Entrez Gene |
28991
|
| Alt Symbol |
HCARG, HT002
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
COMM domain containing 5
|
| Other Description |
COMM domain-containing protein 5|hypertension-related calcium-regulated gene protein
|
| Swissprots |
D3DWN7 Q9GZQ3 Q9UHX5 Q9NVN6
|
| Accessions |
CAD34952 CAE90801 EAW82033 EAW82034 EAW82035 EAW82036 EAW82037 Q9GZQ3 AF113540 AAF14877 AF290195 AAG09915 AK001477 BAA91714 AK023070 BAB14389 AK092477 AW137480 BC002672 AAH02672 BC003055 AAH03055 BC065729 AAH65729 BG705627 BI753202 BM013651 BM924244 BQ680339 BU508224 BU600590 H92104 XR_428379 XR_928321 XR_928322 XR_928323 XR_928324 XR_928325 NM_001081003 NP_001074472 NM_001081004 NP_001074473 NM_001287237 NP_001274166 NM_014066 NP_054785
|
| Function |
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966). {ECO:0000250|UniProtKB:Q9ERR2, ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}.
|
| Tissue Specificity |
Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver. {ECO:0000269|PubMed:10918053, ECO:0000269|PubMed:15799966}.
|