COMMD5

Gene Symbol COMMD5
Entrez Gene 28991
Alt Symbol HCARG, HT002
Species Human
Gene Type protein-coding
Description COMM domain containing 5
Other Description COMM domain-containing protein 5|hypertension-related calcium-regulated gene protein
Swissprots D3DWN7 Q9GZQ3 Q9UHX5 Q9NVN6
Accessions CAD34952 CAE90801 EAW82033 EAW82034 EAW82035 EAW82036 EAW82037 Q9GZQ3 AF113540 AAF14877 AF290195 AAG09915 AK001477 BAA91714 AK023070 BAB14389 AK092477 AW137480 BC002672 AAH02672 BC003055 AAH03055 BC065729 AAH65729 BG705627 BI753202 BM013651 BM924244 BQ680339 BU508224 BU600590 H92104 XR_428379 XR_928321 XR_928322 XR_928323 XR_928324 XR_928325 NM_001081003 NP_001074472 NM_001081004 NP_001074473 NM_001287237 NP_001274166 NM_014066 NP_054785
Function May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966). {ECO:0000250|UniProtKB:Q9ERR2, ECO:0000269|PubMed:15799966, ECO:0000305|PubMed:21778237}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}.
Tissue Specificity Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver. {ECO:0000269|PubMed:10918053, ECO:0000269|PubMed:15799966}.

COMMD5 CRISPR/Cas9 KO Plasmid (h) - sc-407958 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

COMMD5 HDR Plasmid (h) - sc-407958-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COMMD5 Double Nickase Plasmid (h) - sc-407958-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COMMD5 Double Nickase Plasmid (h2) - sc-407958-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COMMD5 CRISPR Activation Plasmid (h) - sc-407958-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

COMMD5 CRISPR Activation Plasmid (h2) - sc-407958-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

COMMD5 Lentiviral Activation Particles (h) - sc-407958-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COMMD5 Lentiviral Activation Particles (h2) - sc-407958-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

COMMD5 siRNA (h) - sc-77657 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

COMMD5 shRNA Plasmid (h) - sc-77657-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

COMMD5 shRNA (h) Lentiviral Particles - sc-77657-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

COMMD5 RNAi - H00028991-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

COMMD5 RNAi - H00028991-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

COMMD5 RNAi - H00028991-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU147281 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6418 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6418 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04085 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04085

COMMD5 siRNA (Human) - CRH9154 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

COMMD5 - MBS8216022 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human COMMD5 (NM_014066.3) - SHH267617 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human COMMD5(NM_001081004.1) - SHG191899 from Creative biogene

Category siRNA
Species Reactivities Human

COMMD5 shRNA Plasmid (Human) - CHH9154 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

COMMD5 miRNA 3'UTR clone - MiUTR1H-02339 from Creative biogene

Species Reactivities Human

COMMD5 miRNA 3'UTR clone - MiUTR3H-09849 from Creative biogene

Species Reactivities Human
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