| Gene Symbol |
Fas
|
| Entrez Gene |
246097
|
| Alt Symbol |
Tnfrsf6
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
Fas cell surface death receptor
|
| Other Description |
CD95 antigen|FASLG receptor|Fas (TNF receptor superfamily, member 6)|Fas antigen (ATP1)|Fas receptor|Tumor necrosis factor receptor superfamily, member 6|apo-1 antigen|apoptosis-mediating surface antigen FAS|tumor necrosis factor receptor superfamily member 6
|
| Swissprots |
Q63199
|
| Accessions |
EDM13158 EDM13159 Q63199 AF104034 AAD20221 CB810875 D26113 BAA05109 FQ233018 NM_139194 NP_631933
|
| Function |
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Proteoglycans in cancer, Herpes simplex infection, TNF signaling pathway, Influenza A, Non-alcoholic fatty liver disease (NAFLD)
|