| Gene Symbol | Fas |
|---|---|
| Entrez Gene | 246097 |
| Alt Symbol | Tnfrsf6 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | Fas cell surface death receptor |
| Other Description | CD95 antigen|FASLG receptor|Fas (TNF receptor superfamily, member 6)|Fas antigen (ATP1)|Fas receptor|Tumor necrosis factor receptor superfamily, member 6|apo-1 antigen|apoptosis-mediating surface antigen FAS|tumor necrosis factor receptor superfamily member 6 |
| Swissprots | Q63199 |
| Accessions | EDM13158 EDM13159 Q63199 AF104034 AAD20221 CB810875 D26113 BAA05109 FQ233018 NM_139194 NP_631933 |
| Function | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Top Pathways | Proteoglycans in cancer, Herpes simplex infection, TNF signaling pathway, Influenza A, Non-alcoholic fatty liver disease (NAFLD) |