| Gene Symbol | HSD11B1 |
|---|---|
| Entrez Gene | 3290 |
| Alt Symbol | 11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | hydroxysteroid (11-beta) dehydrogenase 1 |
| Other Description | corticosteroid 11-beta-dehydrogenase isozyme 1|short chain dehydrogenase/reductase family 26C member 1|short chain dehydrogenase/reductase family 26C, member 1 |
| Swissprots | P28845 D3DT89 B2R9Z1 |
| Accessions | AAC31757 AAK83653 EAW93445 EAW93446 P28845 AK313973 BAG36688 BC012593 AAH12593 BG619051 BM994393 BX345837 CB530075 CF596989 CF597174 DQ892912 ABM83838 EU176721 ABW03522 KJ534869 AHW56509 NM_001206741 NP_001193670 NM_005525 NP_005516 NM_181755 NP_861420 |
| Function | Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity). {ECO:0000250}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10497248}; Single-pass type II membrane protein {ECO:0000269|PubMed:10497248}. |
| Tissue Specificity | Widely expressed. Highest expression in liver. |
| Top Pathways | Steroid hormone biosynthesis, Chemical carcinogenesis, Metabolism of xenobiotics by cytochrome P450 |