HSD11B1

Gene Symbol	HSD11B1
Entrez Gene	3290
Alt Symbol	11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1
Species	Human
Gene Type	protein-coding
Description	hydroxysteroid (11-beta) dehydrogenase 1
Other Description	corticosteroid 11-beta-dehydrogenase isozyme 1|short chain dehydrogenase/reductase family 26C member 1|short chain dehydrogenase/reductase family 26C, member 1
Swissprots	P28845 D3DT89 B2R9Z1
Accessions	AAC31757 AAK83653 EAW93445 EAW93446 P28845 AK313973 BAG36688 BC012593 AAH12593 BG619051 BM994393 BX345837 CB530075 CF596989 CF597174 DQ892912 ABM83838 EU176721 ABW03522 KJ534869 AHW56509 NM_001206741 NP_001193670 NM_005525 NP_005516 NM_181755 NP_861420
Function	Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity). {ECO:0000250}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:10497248}; Single-pass type II membrane protein {ECO:0000269|PubMed:10497248}.
Tissue Specificity	Widely expressed. Highest expression in liver.
Top Pathways	Steroid hormone biosynthesis, Chemical carcinogenesis, Metabolism of xenobiotics by cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HSD11B1 293T Cell Transient Overexpression Lysate(Denatured) - H00003290-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

HSD11B1 293 Cell Lysate - 401522 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

HSD11B1 293 Cell Lysate - 403663 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

11 beta-HSD1 Overexpression Lysate (Denatured) - H00003290-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

11 beta-HSD1 Overexpression Lysate (Native) - NBL1-11719 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

11 beta-HSD1 Overexpression Lysate (Native) - NBL1-11718 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

HSD11B1 Over-expression Lysate Product - GWB-CFA159 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

HSD11B1 Over-expression Lysate Product - GWB-43A00A from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

11 beta-HSD1 Overexpression Lysate (Denatured) - H00003290-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human HSD11B1 Knockdown Stable Cell Line - CSC-DC007271 from Creative biogene Category Cell Line Species Human

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