HSD11B1

Gene Symbol HSD11B1
Entrez Gene 3290
Alt Symbol 11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1
Species Human
Gene Type protein-coding
Description hydroxysteroid (11-beta) dehydrogenase 1
Other Description corticosteroid 11-beta-dehydrogenase isozyme 1|short chain dehydrogenase/reductase family 26C member 1|short chain dehydrogenase/reductase family 26C, member 1
Swissprots P28845 D3DT89 B2R9Z1
Accessions AAC31757 AAK83653 EAW93445 EAW93446 P28845 AK313973 BAG36688 BC012593 AAH12593 BG619051 BM994393 BX345837 CB530075 CF596989 CF597174 DQ892912 ABM83838 EU176721 ABW03522 KJ534869 AHW56509 NM_001206741 NP_001193670 NM_005525 NP_005516 NM_181755 NP_861420
Function Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity). {ECO:0000250}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:10497248}; Single-pass type II membrane protein {ECO:0000269|PubMed:10497248}.
Tissue Specificity Widely expressed. Highest expression in liver.
Top Pathways Steroid hormone biosynthesis, Chemical carcinogenesis, Metabolism of xenobiotics by cytochrome P450

11β-HSD1 siRNA (h) - sc-41377 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

11β-HSD1 shRNA Plasmid (h) - sc-41377-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

11β-HSD1 shRNA (h) Lentiviral Particles - sc-41377-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

11 beta-HSD1 RNAi - H00003290-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU043531 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10319 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10319 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03784 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03784

HSD11B1 siRNA (Human) - CRH2247 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

11 beta-HSD1 RNAi - H00003290-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

HSD11B1 - MBS8217427 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HSD11B1 (NM_005525.3) - SHH315105 from Creative biogene

Category siRNA
Species Reactivities Human

Human HSD11B1 siRNA - orb262749 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HSD11B1 shRNA Plasmid (Human) - CHH2247 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HSD11B1 miRNA 3'UTR clone - MiUTR3H-03584 from Creative biogene

Species Reactivities Human

HSD11B1 miRNA 3'UTR clone - MiUTR3H-03585 from Creative biogene

Species Reactivities Human
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