| Gene Symbol |
LYVE1
|
| Entrez Gene |
10894
|
| Alt Symbol |
CRSBP-1, HAR, LYVE-1, XLKD1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lymphatic vessel endothelial hyaluronan receptor 1
|
| Other Description |
cell surface retention sequence binding protein-1|cell surface retention sequence-binding protein 1|extracellular link domain containing 1|extracellular link domain-containing 1|extracellular link domain-containing protein 1|hyaluronic acid receptor|lymphatic vessel endothelial hyaluronic acid receptor 1
|
| Swissprots |
Q9Y5Y7 Q8TC18 Q9UNF4
|
| Accessions |
CAI72127 EAW68565 Q9Y5Y7 AF118108 AAD42764 AF127670 AAD49220 AK075443 BAG52138 AK300885 BAG62527 AK312462 BAG35369 AY358925 AAQ89284 BC026231 AAH26231 CA449932 DA924658 DQ892040 ABM82966 DQ895232 ABM86158 NM_006691 NP_006682
|
| Function |
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. {ECO:0000269|PubMed:10037799}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:10037799}; Single-pass type I membrane protein {ECO:0000269|PubMed:10037799}. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand- dependent internalization and recycling at the cell surface.
|
| Tissue Specificity |
Mainly expressed in endothelial cells lining lymphatic vessels. {ECO:0000269|PubMed:10037799}.
|
![Western Blot: LYVE1 Overexpression Lysate (Adult Normal) [NBL1-12770] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LYVE1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6609_LYVE1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12770-img0002.jpg)