LYVE1
| Gene Symbol | LYVE1 |
|---|---|
| Entrez Gene | 10894 |
| Alt Symbol | CRSBP-1, HAR, LYVE-1, XLKD1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | lymphatic vessel endothelial hyaluronan receptor 1 |
| Other Description | cell surface retention sequence binding protein-1|cell surface retention sequence-binding protein 1|extracellular link domain containing 1|extracellular link domain-containing 1|extracellular link domain-containing protein 1|hyaluronic acid receptor|lymphatic vessel endothelial hyaluronic acid receptor 1 |
| Swissprots | Q9Y5Y7 Q8TC18 Q9UNF4 |
| Accessions | CAI72127 EAW68565 Q9Y5Y7 AF118108 AAD42764 AF127670 AAD49220 AK075443 BAG52138 AK300885 BAG62527 AK312462 BAG35369 AY358925 AAQ89284 BC026231 AAH26231 CA449932 DA924658 DQ892040 ABM82966 DQ895232 ABM86158 NM_006691 NP_006682 |
| Function | Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. {ECO:0000269|PubMed:10037799}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:10037799}; Single-pass type I membrane protein {ECO:0000269|PubMed:10037799}. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand- dependent internalization and recycling at the cell surface. |
| Tissue Specificity | Mainly expressed in endothelial cells lining lymphatic vessels. {ECO:0000269|PubMed:10037799}. |
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