| Gene Symbol |
RRAGB
|
| Entrez Gene |
10325
|
| Alt Symbol |
RAGB, bA465E19.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras-related GTP binding B
|
| Other Description |
GTP-binding protein ragB|rag B|ras-related GTP-binding protein B
|
| Swissprots |
Q8N3T0 Q15348 Q5VZM2 A8K042
|
| Accessions |
EAW93227 EAW93228 EAW93229 Q5VZM2 AK289407 BAF82096 AL831926 CAD38586 BC034726 AAH34726 BX641797 CD676755 DB246060 DB252202 EU831588 ACE87188 EU831673 ACE86507 X90530 CAA62132 XM_005261973 XP_005262030 XM_005261975 XP_005262032 XR_244464 XR_244465 XR_430513 XR_938361 NM_006064 NP_006055 NM_016656 NP_057740
|
| Function |
Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. {ECO:0000269|PubMed:18497260, ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:9394008}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:7499430}. Lysosome.
|
| Top Pathways |
mTOR signaling pathway
|