| Gene Symbol |
CRYZ
|
| Entrez Gene |
1429
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
crystallin, zeta (quinone reductase)
|
| Other Description |
NADPH:quinone reductase|quinone oxidoreductase
|
| Swissprots |
Q59EU7 Q53FT0 Q6NSK9 D3DQ76 A6NN60 Q08257 Q5HYE7
|
| Accessions |
AAK40311 EAX06409 EAX06410 EAX06411 EAX06412 Q08257 AB209714 BAD92951 AK123469 AK128794 AK223150 BAD96870 AK223201 BAD96921 AK314813 BC039578 AAH39578 BC070058 AAH70058 BX647883 CAI46072 BX649061 CN368109 DA256305 L13278 AAA36536 XM_005270491 XP_005270548 XM_011540747 XP_011539049 NM_001130042 NP_001123514 NM_001130043 NP_001123515 NM_001134759 NP_001128231 NM_001889 NP_001880
|
| Function |
Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. {ECO:0000269|PubMed:17497241, ECO:0000269|PubMed:20103721}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:20103721}.
|
| Tissue Specificity |
Only very low amounts in the lens.
|