Gene Symbol | CRYZ |
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Entrez Gene | 1429 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | crystallin, zeta (quinone reductase) |
Other Description | NADPH:quinone reductase|quinone oxidoreductase |
Swissprots | Q59EU7 Q53FT0 Q6NSK9 D3DQ76 A6NN60 Q08257 Q5HYE7 |
Accessions | AAK40311 EAX06409 EAX06410 EAX06411 EAX06412 Q08257 AB209714 BAD92951 AK123469 AK128794 AK223150 BAD96870 AK223201 BAD96921 AK314813 BC039578 AAH39578 BC070058 AAH70058 BX647883 CAI46072 BX649061 CN368109 DA256305 L13278 AAA36536 XM_005270491 XP_005270548 XM_011540747 XP_011539049 NM_001130042 NP_001123514 NM_001130043 NP_001123515 NM_001134759 NP_001128231 NM_001889 NP_001880 |
Function | Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. {ECO:0000269|PubMed:17497241, ECO:0000269|PubMed:20103721}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:20103721}. |
Tissue Specificity | Only very low amounts in the lens. |
ζ-crystallin siRNA (h) - sc-106887 from Santa Cruz Biotechnology
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ζ-crystallin shRNA Plasmid (h) - sc-106887-SH from Santa Cruz Biotechnology
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ζ-crystallin shRNA (h) Lentiviral Particles - sc-106887-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU158621 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6619 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6619 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12320 from Sigma-Aldrich
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CRYZ siRNA (Human) - CRH1005 from Cohesion Biosciences
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CRYZ RNAi - H00001429-R01 from Novus Biologicals
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CRYZ - MBS8228250 from MyBioSource
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shRNA set against Human CRYZ (NM_001889.3) - SHH270105 from Creative biogene
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Human CRYZ siRNA - orb261507 from Biorbyt
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CRYZ shRNA Plasmid (Human) - CHH1005 from Cohesion Biosciences
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CRYZ miRNA 3'UTR clone - MiUTR3H-00551 from Creative biogene
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CRYZ miRNA 3'UTR clone - MiUTR3H-00552 from Creative biogene
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CRYZ miRNA 3'UTR clone - MiUTR3H-00553 from Creative biogene
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CRYZ miRNA 3'UTR clone - MiUTR3H-00554 from Creative biogene
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