TANK

Gene Symbol TANK
Entrez Gene 10010
Alt Symbol I-TRAF, ITRAF, TRAF2
Species Human
Gene Type protein-coding
Description TRAF family member-associated NFKB activator
Other Description TRAF family member-associated NF-kappa-B activator|TRAF-interacting protein
Swissprots Q92844 Q7Z4J6 D3DPB5 Q92885
Accessions AAX88939 AAY14785 EAX11374 EAX11375 EAX11376 EAX11377 Q92844 AK313096 BAG35920 BC003388 AAH03388 BC067779 AAH67779 BT009855 AAP88857 U59863 AAC50681 U63830 AAC50770 XM_005246207 XP_005246264 XM_005246208 XP_005246265 XM_005246210 XP_005246267 XM_005246211 XP_005246268 XM_011510455 XP_011508757 NM_004180 NP_004171 NM_133484 NP_597841 NM_001199135 NP_001186064
Function Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631}.
Subcellular Location Cytoplasm.
Tissue Specificity Ubiquitous.
Top Pathways RIG-I-like receptor signaling pathway

TANK Antibody - 2141 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from ACHN (human), PC-12 (rat) and A20 (mouse), using TANK Antibody.

TANK (B-12) - sc-373923 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TANK (B-12): sc-373923. Western blot analysis of TANK expression in Ramos whole cell lysate.

TANK (D-2) - sc-166643 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TANK (D-2): sc-166643. Western blot analysis of TANK expression in Ramos (A), Jurkat (B), HCT 116 (C), HeLa (D), HL-60 (E) and KNRK (F) whole cell lysates.

TANK (H-10) - sc-374189 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TANK (H-10): sc-374189. Western blot analysis of TANK expression in Ramos whole cell lysate.

TANK (A-7) - sc-166642 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TANK (A-7): sc-166642. Western blot analysis of TANK expression in Jurkat (A) and HL-60 (B) whole cell lysates.

TANK (H-300) - sc-8314 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TANK (H-300): sc-8314. Western blot analysis of TANK expression in Ramos (A) and Jurkat (B) whole cell lysates.

TANK (C-20) - sc-1997 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TANK (C-20): sc-1997. Western blot analysis of TANK expression in Ramos whole cell lysate.

TANK (N-19) - sc-1998 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TANK (N-19): sc-1998. Western blot analysis of TANK expression in Ramos whole cell lysate.

Anti-TANK antibody - ab18819 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab18819 stained HeLa cells. The cells were 4% PFA fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab18819, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-TANK antibody - ab47632 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TANK antibody (ab47632) at 0.5 µg/mlLane 2 : Anti-TANK antibody (ab47632) at 1 µg/mlLane 3 : Anti-TANK antibody (ab47632) at 2 µg/mlLane 1 : Daudi Cell LysateLane 2 : Daudi Cell LysateLane 3 : Daudi Cell LysateLysates/proteins at 15 µg per lane.

Anti-TANK antibody - ab47633 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TANK antibody (ab47633) at 0.5 µg/mlLane 2 : Anti-TANK antibody (ab47633) at 1 µg/mlLane 1 : Daudi cell lysate at 15 µg per lane.Lane 2 : Daudi cell lysate at 15 µg per lane.SecondaryAnti-rabbit IgG HRP at 1:10000

Anti-TANK antibody - ab65138 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TANK antibody (ab65138) at 1/500 dilutionLane 1 : Extracts from HT-29 cellsLane 2 : Extracts from HT-29 cells, plus immunising peptide

Anti-TANK antibody - ab169098 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-TANK antibody (ab169098) at 1/500 dilutionLane 1 : TANK-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-TANK antibody - C-terminal - ab188876 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-TANK antibody - C-terminal (ab188876) at 0.5 µg/mlLane 2 : Anti-TANK antibody - C-terminal (ab188876) at 1 µg/mlLane 3 : Anti-TANK antibody - C-terminal (ab188876) at 2 µg/mlLane 1 : Daudi cell lysateLane 2 : Daudi cell lysateLane 3 : Daudi cell lysate

Anti-TANK Antibody (aa171-220) - LS-C199150 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HT29 cells, using I-TRAF Antibody. The lane on the right was incubated with synthetic peptide.

Anti-TANK Antibody - LS-C334931 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of HeLa cell using TANK antibody. Blue: DAPI for nuclear staining.

Anti-TANK Antibody (aa88-114) - LS-C161697 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TANK Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human cervix carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-TANK Antibody (C-Terminus) IHC-plus™ - LS-B595 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TANK antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B595 concentration 5 ug/ml.

Anti-TANK Antibody (N-Terminus) IHC-plus™ - LS-B1409 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TANK antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1409 concentration 5 ug/ml.

Anti-TANK Antibody (Ser357) - LS-C39770 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TANK Antibody - LS-C76469 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-TANK Antibody (C-Terminus) - LS-C30210 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: Jurkat Cell Lysate

Anti-TANK Antibody - LS-C96015 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal

Anti-TANK Antibody - LS-C48332 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of TANK antibody LS-C48332.

Anti-TANK Antibody (aa346-367) - LS-C148273 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
IHC of TANK/I-TRAF1 expression in formalin-fixed, paraffin-embedded normal human colon using LS-C148273 at 1:2000. A-A3, low and high magnification images. Hematoxylin-Eosin counterstain.
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