Gene Symbol | TANK |
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Entrez Gene | 10010 |
Alt Symbol | I-TRAF, ITRAF, TRAF2 |
Species | Human |
Gene Type | protein-coding |
Description | TRAF family member-associated NFKB activator |
Other Description | TRAF family member-associated NF-kappa-B activator|TRAF-interacting protein |
Swissprots | Q92844 Q7Z4J6 D3DPB5 Q92885 |
Accessions | AAX88939 AAY14785 EAX11374 EAX11375 EAX11376 EAX11377 Q92844 AK313096 BAG35920 BC003388 AAH03388 BC067779 AAH67779 BT009855 AAP88857 U59863 AAC50681 U63830 AAC50770 XM_005246207 XP_005246264 XM_005246208 XP_005246265 XM_005246210 XP_005246267 XM_005246211 XP_005246268 XM_011510455 XP_011508757 NM_004180 NP_004171 NM_133484 NP_597841 NM_001199135 NP_001186064 |
Function | Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Ubiquitous. |
Top Pathways | RIG-I-like receptor signaling pathway |
TANK - MBS1268019 from MyBioSource
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TANK - MBS1270192 from MyBioSource
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Human TANK cDNA clone(NM_133484.1) - CDFG007766 from Creative Biomart
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Human TANK cDNA clone(NM_004180.2) - CDFH019201 from Creative Biomart
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Human TANK ORF Clone(NM_004180.2) - CDCR287349 from Creative Biomart
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Human TANK ORF Clone(NM_004180.2) - CDCR287350 from Creative Biomart
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Human TANK ORF Clone(NM_133484.1) - CDCR316120 from Creative Biomart
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Human TANK ORF Clone(NM_133484.1) - CDCR316121 from Creative Biomart
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Human TANK ORF Clone(NM_004180.2) - CDCL177830 from Creative Biomart
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human TANK ORF clone - CDCH088712 from Creative Biomart
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human TANK ORF clone - CDCH088713 from Creative Biomart
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human TANK ORF clone - CDCH088720 from Creative Biomart
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human TANK ORF clone - CDCH088721 from Creative Biomart
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human TANK ORF clone - CDCH088722 from Creative Biomart
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human TANK ORF clone - CDCH088723 from Creative Biomart
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Human TANK Gene cDNA Clone (full-length ORF Clone) - HG16513-G from Sino Biological
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Human TANK natural ORF mammalian expression plasmid, N-GFPSpark tag - HG16513-ANG from Sino Biological
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Human TANK natural ORF mammalian expression plasmid, N-HA tag - HG16513-NY from Sino Biological
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Human TANK natural ORF mammalian expression plasmid, C-OFPSpark / RFP tag - HG16513-ACR from Sino Biological
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Human TANK natural ORF mammalian expression plasmid, N-OFPSpark / RFP tag - HG16513-ANR from Sino Biological
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Human TANK natural ORF mammalian expression plasmid, N-His tag - HG16513-NH from Sino Biological
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Human TANK natural ORF mammalian expression plasmid, C-Flag tag - HG16513-CF from Sino Biological
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Human TANK Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-tagged - HG16513-NF from Sino Biological
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Human TANK natural ORF mammalian expression plasmid - HG16513-UT from Sino Biological
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Human TANK Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-tagged - HG16513-CH from Sino Biological
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